Convenia Long-Acting Antibiotic Injection

“Awwww, Doc, can’t you just give him a shot?”

Usually that question comes from a pet lover in the form of an objection to having to give oral medications for a two week or longer time period. Up until now our answer has been, “No, an antibiotic injection will last 12 to 24 hours, then we would have to give another one. Do you want to come in every day for 14 days for injections at $35.00 each?”

But the times, they are a’changing.

Enter Convenia, (cefovecin sodium) the long-acting antibiotic from Pfizer Animal Health that lasts 10 to 14 days with a single injection. Convenia is more than just penicillin. It’s a broad-spectrum antibiotic (in the simplest terms that means it kills a lot of different kinds of bacteria), so it can be used in a wide variety of infected organ systems and clinical and hospital situations.

Convenia isn’t right for every infection. If it were, it would be the only antibiotic on the market. Instead, there are hundreds and hundreds of antibiotics, each with a situation or organism on which it works best.

If my pet were a patient, I would sure ask my pet’s doctor if Convenia (cefovecin sodium) were right for him.

covenia, convina, convinia, covinia

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Dr. Randolph
Articles: 949


  1. My dog (13 male) just had double TECA surgery. I can’t get him to take his meds from the surgeon – I was given 3 mandatory & 1 to use as needed (to keep him calm). One is a liquid (for inflammation & pain) that I finally got him to take tonight in pumpkin puree, but the pills start to dissolve in the wet food, then he tastes it (probably bitter) and refuses to eat anymore. I’m not so much worried about the codeine (pain reliever) as hopefully the anti-inflammatory/pain combo will be enough (he’s not whining or appearing in pain). But I am concerned about him not taking the antibiotic. Do you think Convenia would be a good solution? I only have one hand so can’t really force things in his mouth – plus he’s been nippy/biting since the surgery when anyone tries that. Thanks!

    • Convenia is a good antibiotic for infections of the skin, but only his veterinarian can make the call on whether it’s appropriate in this situation. And, you’re going to have to talk to the doctor to get a Convenia injection anyway, so give them a call. Thanks for reading, Dr. Randolph.

  2. Convenia was a suggested antibiotic for aspiration pneumonia in yorkie puppies. What are your thoughts on this and have you heard of there being success for administering convenia in this manor? Is there an age/weight guideline in small breed puppies? Yorkie puppies as small as 3 ounces and up. What are the side effects?

  3. I took my cat to the vet, and he diagnosed her as having an infected salivary gland. He recommended using Covenia as he wants her to have a total of 4 injections over the course of 2 months. I have used Covenia in the past with great success. Unfortunately, he didn’t have any available that day, but said he would overnight the medicine via the post office later that week given that it is a 10-hr round trip drive for me to get there, and I have to pay $160 for gas and to take my car on a ferry (I live on an isolated peninsula).

    The medicine actually took 2 days to arrive and was shipped in a small, non-insulated metal thermos. There was melted water in the thermos, presumably from a couple of ice cubes. However, by the time I received it, the water was room temperature.

    The Covenia instructions state it needs to be stored both in its powder and reconstituted forms at 36-46 degrees Fahrenheit. The water & inside of the thermos were definitely not that cold – 65-70 degrees F at best.

    My vet says it should still be okay since it was unrefrigerated for only a short time. He will not refund my money or send a new bottle. I am skeptical but do not want to pay another $200 for a new bottle (not to mention the same problem of how to get it to my house). I am frustrated because I have no way of knowing if it is still good or not except to simply use it and hope that it works and helps my sick cat.

    What do you think??

    • I think I would have already been on the phone to suspected adverse event“>Zoetis and asked them their opinion. You will find the staff there professional and happy to help. Please keep in mind that the financial transaction was between you and the doctor, I wouldn’t expect Zoetis to feel obligated to replace the vial for you, but they should be able to at least render an opinion on whether the cefovecin is still active. I’d be interested in knowing how this is resolved for you, if you don’t mind posting the outcome for us. Thank you.

  4. My cat was given Convenia after having some skin allergic issues below his ears. He now has a bad respiratory infection, sneezing hacking. Is this normal?

  5. hi, my 4yrs 9moth lurcher/staffie cross was given convenia approx 2 months ago. she seems a little down in herself and over the past 3 days i have noticed a small amount of urine dripping from her. Do you think this could be a side effect of convenia? and is there anything I can do for her, she’s seeing the vet that gave her the injection today but I’m not sure they would be forthcoming about it being down to the convenia as the they told me at the time there were no side effects to this injection (when i specifically asked would there be any side effects). I’m terribly worried about her.
    thank you .

    • Two months ago? That’s a bit of a reach, don’t you think? The bottom line is, if you see your pet’s doctor today and you still think her health problems are Convenia-related, you can contact Zoetis and file a report with them about a suspected adverse event. We will be very interested to know the outcome of her case, and would greatly appreciate a followup report. Thank you for reading.

      • Hi there, she was seen by her vet yesterday, he says her symptoms are not related to the injection ( I wasn’t blaming the injection, i was just concerned it may have been a factor), she has been on steroids and he thinks between the steroids and her being neutered (the incontinence being down to this) that he is not concerned about her. its put my mind at rest, I know I sound like an overbearing mother but she means the world to me.
        shes off the steroids now and hopefully in the next few days she’ll be back to normal.
        thank you very much for replying.
        best wishes.

  6. Hi Dr. Randolph, so I have Bengal cat. He’s about 9 to 10 years old, we don’t know for sure cause he showed up at home and never left. He had some dental issues a month ago, so he got two neck lesions extraction last April 4th. I was happy thinking that he’d be back to himself. About 12 days later after procedure I noticed he was having foul odor coming out his mouth, and he was putting his paw on his mouth over and over. Plus he was having trouble bathing, like something in his mouth was bothering him. I took him to vet, she said he got an infection. She gave him two shots Convenia and Penicillin. This was 2days ago. He’s not having any problem eating his can food. But I can tell he is in a lot pain, he’s very demotivated, put his paw on his mouth a lot. Not playful, don’t want lap (that’s his favorite thing). I’m so frustrated. I don’t know how long it takes to kick in. I’m so afraid to lose my baby Kitty

    • If I were in your situation, I would seek the advice of a board-certified veterinary dentist. You may have to drive to a nearby larger city, but it will be time well-spent. If there is going to be a delay before you can see the dentist, ask your local veterinarian to run these laboratory tests in the meantime. Please write back and let me know what is found. Thank you for reading, Dr. Randolph.

  7. My beloved rescue Norweigan Forest Cat Wedgie had a lick granuloma that made his right back paw look like a “Fred Flinstone Foot”. He received Convenia last Friday and yesterday gradually lost coordination in his back legs. He is awake and alert and eats when I hand feed. He is literally hanging out in his litter box (not great for the granuloma) so I put him in his bed nearby. He almost looks like a person with Guillian Barre. Yes I am taking him in to the vet but I want to be mentally ready for the diagnosis—med side effect? will it resolve or is this a terminal event?


  8. My 11 year old Yorkie was given Convenia yesterday for pancreatitis. This was not his first episode, but was the first time receiving this injection. But the vet also said that he needed Flagyl to cover what Convenia didn’t. He’s had Flagyl in the past, but was given 250 mg twice a day (a previous vet’s dosing.) However, with this current vet, he was prescribed 1/4 of 250 mg twice a day. That just doesn’t seem sufficient, especially when I read the minimum dosing is 11 mg per kg of body weight, which he is 13 pounds. Was he prescribed less because he had the Convenia? On a side note, my dog NEVER eats table scraps and has been on a low fat diet for the past three years of Hills W/D and Royal Canin Gastrointestinal Low Fat. It’s interesting that he has no diarrhea, but I saw that he had vomited (I assume) frank bright blood. There was nothing in it so it’s hard to tell which end it came from. His pancreatitis test was positive. I just want to make sure he’s getting all the right medication at the right dose.

    • In my experience, metronidazole is one of those drugs I’ve seen doctors use a WIDE range of doses with success. I wouldn’t think that dose would result in problems, but, if he’s not doing well enough Tuesday when the doctor reopens, you can ask him/her to reconsider the dose. Pancreatitis is a tricky condition. Sometimes you do everything right and it still does whatever it wants to. Still, keep doing all of the preventive measures and you maximize your chances of avoiding at least some episodes. Thanks for reading

  9. Well, thankfully the 2 week (14 days) mark of Convenia is today. She seemed to tolerate it ok, but I read that the drug still stays in their system for up to 2 months. ” It exerts its antibacterial effects for approximately 1-2 weeks but stays in the body for over 2 months.” I am not sure what that means…what exactly stays in their system? and what is the potential harm? Does anyone know? Thank you.  

  10. My cat was given a shot of Convenia today for suspected UTI. I did ask vet about side effects and she said they tolerate it well. Well, my cat has been walking funny and basically limping since she came home. She is eating and seems ok. Obviously, she was not limping before so it could only be the Convenia. Is this a possible side effect with Convenia and will it go away. My cat is 19 and only 5 lbs. she does not need further complications. Thank you.

  11. My 15 yo cat started sneezing last Sunday. (My other cat had just been treated for a URI, so I was not surprised.) I took him to the vet Monday to try to catch it early. He was given a convenina injection and meds in his ears for additional ear infection.

    It is now Saturday – 5 days since the injection – and my cat is ten times worse. His eyes are running, his nose is congested and running, and every so often he “snorts” like he’s having difficulty breathing. I called my vet on Wednesday to tell them he was getting worse and was told “it will get worse before it gets better”.

    How long before I should see improvement from the injection? This seems highly abnormal.

    • Actually, it’s exactly what one might expect. It’s the reason your pet’s doctor said, “it will get worse before it gets better.” Most of these patients are infected with a combination of viruses, bacteria and, sometimes, Chlamydia. Click here to read more. That said, some of these patients also need supportive therapy, such as IV fluids, nose cleaning, nebulization, sometimes other modes of therapy. Such treatment is usually provided by emergency clinics, but your veterinarian may provide 24-hour care. Check with him/her. Thanks for reading

  12. Our 5 year old cat was diagnosed with IMHA a little over 2 years ago. We have “managed” this illness with Prednisolone and CellCept — PCV goes up (high as 34) and down (low as 15) and we have been unable to reduce dosage without PCV dropping. She occasionally has had bouts of severe sneezing with nasal discharge and our vet has given Covenia which always clears up the issue in a few days. At our last visit, we were told that her kidneys were enlarged and she was given a Covenia injection. Considering her health history, should a different antibiotic be used? It has been 5 days since the injection and her kidneys are still palpable/enlarged. Thank you in advance for your reply.

    • Hmmmmmm … I’ve wracked my brain, and I can’t come up with a single scenario in which enlargement of the kidneys would be related to Convenia. The next step, diagnostically, if you wanted to pursue it, would be ultrasound of the kidneys. However, unless the enlargement is significant, or urine output is reduced, or she is feeling poorly, I’m not convinced it’s something to pursue. Thanks for reading

      • Dr. Randolph, Thank you so much for your reply. We realize we are fighting a losing battle with primary IMHA and would surmise the kidney enlargement is a result of the disease and the long term steroid use (substantial dosage — 10mg twice per day and our girl weighs 10 lbs) . Unfortunately, we are unable to reduce the dosage; each time we have attempted to reduce (sometimes by as little as 1/4 pill) her PCV starts to drop. The Convenia injection was simply a “what if she has infection?” possible solution to the kidney enlargement. She has a good appetite, urine output is not reduced, she is drinking slightly more water than usual but not by a substantial amount, and doesn’t appear to be in any pain. I think she is somewhat uncomfortable because she no longer sleeps on her back. We have fought a good fight and will continue to do all we can do until we cannot do any more and her quality of life is diminished/she is in pain that cannot be alleviated. We love her dearly. Thank you again for your reply.

  13. Last night I began noticing my cat was going into his litter box an awful lot. This morning I checked the box and noticed there was nothing in there. Then, I witnessed him go into the litter box several times again and nothing was coming out while he was trying to urinate. So I took him to the vet and they gave him Convenia and Dexamethasone. When they brought him back out into the waiting room, he was meowing like I had never heard before. On our way home, he defecated in his crate (which is SO not like him) and continued meowing. We only live a few minutes away from our vet. When we got home, he ran to his bed and began defecating again, then laid in it. He has been so lethargic since we got home about 6 hours ago. He has thrown up several times, as well. He also keeps lying in front of his water bowl and, not drinking it, but instead just lying there and looking at it. He has dipped his paw in several times and shook it off. He also urinated on our bathroom floor and we noticed blood in it. Before taking him to the vet, he was not urinating blood. When the vet helped him to urinate a little when we got there, there was no blood. Before taking him to the vet, he seemed to be fine (eating, walking around, playing, relaxing, etc.). This all started happening after leaving the vet office.

    • I’ve had a very busy few days, so it took longer than usual to reply. I’m sure you’ve been back to have your doctor evaluate this baby since you wrote. What you describe is very unusual. What is the latest. I will eagerly await your reply.

  14. Hello,

    Last Sunday I came home to a suddenly very sick kitty. She was fine at 9am when I left the house but by midnight not so much. She had stopped eating, was vomiting, and felt really warm. I was feeling about the same myself, so I figured I would see what Monday brought us. She wasnt as warm, but definitely lethargic, amd not eating. That night, at 3am she threw up again. So Tuesday we went right in to the vet. They gave her fluids, a dose of mirtazapine, and ordered bloodwork and urinalysis. Her temp was 103.5 or .8. I dont remember exactly. I also fed her later that day with a dropper a mix of vitamin gel and water since the not eating was still occurring. She kept that down but threw up again that night (its bile everytime). She had become less lethargic but still not her normal self. Weds the vet called and said she had an elevated white blood cell count with toxic neutrophils and bands. She thought it was “a weird infection” and was definitely not an old cat disease (mariah is 11.5. Normal weight is 12 or so. She was 9.8 at the vet visit) with the liver or kidneys. The urinalysis came back fine. We gave mariah a shot of convenia and they gave me some hills urgent care a/d and a syringe to feed her. By Weds she had started drinking on her own. And peeing. A lot. Which makes sense since we loaded her up on fluids and I was giving her lots of baths and doing all sorts of messy things she didnt like. Its now Friday and shes still not eating on her own. Shes motoring around the house more and is slightly better but I am still worried. Any thoughts would be appreciated.

    • I would want to see an updated CBC, for starters. How old is Mariah? And, keep pouring the food to her. She needs the nutrients to heal, and to protect her liver until her appetite is back to full. I await your reply, Dr. Randolph.

  15. My four year old Sheltie was given convenia shot for pneumonia .. When I researched this drug I found no example anywhere of it being used for that condition. What do you think?

  16. My 6 yr old cat ate a bug or something. I’m no longer letting her out of the house.. She started licking her butt and not eating. Vet said she probably ate something she shouldn’t have. She got the convenia shot. 3 days now and she is no longer licking (good sign) but her appetite is gone. She drinks the juice from her canned food. Have seen her take a few bites of her dry food (Royal Canin SO) Is it going to take a while for her to get her appetite back? Some days she will take her treats and sometimes not…..

  17. Dr. Randolph, we could really use your advice. I took my 16 year old cat, Sweetie, into the vet for a regular checkup as she had inappropriately urinated outside of her litter box (3) times over (3) months. In the past she had done this when she had some abscessed teeth, so I wanted to see what she was trying to tell us. The vet suggested routine blood work and urine analysis and this showed us that she had elevated BUN and Creatine levels, along with elevated white blood cells – they explained that meant she had early renal/kidney failure then went on to tell me that they also found signs of an upper urinary tract infection and recommended an antibiotic to cure it. They said i could come in the very next day to get the shot and it would last for 2 weeks to clear the infection and we should be able to manage the kidneys with a diet. I was not made aware of any possible side effects or risks with this shot, they really urged that it was the best option. After getting all of this news, I wanted to do anything I can to help her, the last thing I want is for her to be in pain.

    The night she got the shot I noticed she wasn’t up in bed with us, very odd for her – I went downstairs and saw her hovering and shaking. She had vomited her food up. She was moving all around the kitchen, acting like she was trying to pee but couldn’t. There was a clear, viscous fluid that she was excreting. It had no smell, when i wiped it up with paper towel, it had a reddish tinge. Once we put her in her white bed, we saw it was more red but then quickly stopped. I called the emergency vet line and they said I could either watch her overnight or bring her in for x-rays to check for stones. Since it was already after midnight, we decided to see how she was first thing in the morning. About an hour later she was purring in her bed so I thought perhaps the worst had passed.

    I did some research about Convenia online and immediately became so outraged that the vet never gave us any indication of any risks or side effects. I get that a lot of information online is false, but when literally everything you review is negative, its hard not to worry.

    Over the next couple days she was acting very different, distancing herself from us, laying there with her eyes open, not wanting affection, drinking an exorbitant amount of water, still had a really good appetite.

    I took her into the vet again for a follow up and they did blood work again and tried to get another urine sample but couldn’t retrieve one. The blood work came back that her BUN/Creatine levels were getting worse. They claimed no knowledge of risks to Convenia. They gave her some sub-q fluids to help with her dehydration and said to keep an eye on her.

    A few more days pass and she develops diarrhea. I take her into a different vet to get a second opinion and they run another blood test. Her BUN/Creatine levels are getting better but she still shows signs of early renal/kidney failure. They haven’t done a culture on her urine to see about the UTI as they were concerned it would be a false reading due to the convenia. They suggested administering at home sub-q fluids once a week to help with hydration/help her kidneys keep up. They also prescribe Metronidazole for the diarrhea. They said i should think about getting another urine culture done in a couple of weeks.

    She seems like she is slowly getting better but she still lays with her eyes open, staring into space, she doesnt want affection the way she used to, doesnt want to be picked up, is still more solitary/distant than she used to be, her focus is food and water and more food and more and more water, her stools are harder but not yet back to normal.

    I read the medical study regarding Convenia from European Medicines Agency – it specifically says “Convenia should not be used in dogs or cats of less than 8 weeks old, or in dogs or cats with kidney problems (renal dysfunction). So with this information, it makes me wonder why they would ever risk giving my cat, who showed clear signs of kidney/renal failure in her blood work? She was fine before she had the shot – showing no signs of anything wrong with her kidneys. It also makes sense to me that due to her now compromised kidneys, it will take her longer to process the Convenia shot – can you give any advice on this or how I can help he get back to normal faster? I dont want her to be in pain. Thank you very much for taking the time to read my story and let us know your opinion, I sure appreciate it.

  18. Dear Dr. Randolph:

    My 7 y/o cat, Cyrus, is one I adopted from my vet clinic at 10 mos. old. Someone found him on the side of the road with a severely infected eye at 4 weeks old, and took him to my vet, who had to remove his eye due to the infection. Thereafter, I adopted him at 10 weeks old, got him neutered and front claws removed, and he became my loving indoor baby.

    However, he is a biter, no matter how much I treat him with respect and love. I think he has chemical imbalances in the brain, but when the vet prescribed pills to give him to improve his disposition, after a week he learned to get rid of any pill I hid in food and it was impossible to put it down his throat due to serious biting.

    So here now 5 years later, he is my neurotic baby, and I do know when to leave him alone and when he wants love. But he has separation anxiety and cannot stand for me to leave the house. He has bitten me to the extreme many times over the past 6 years, and I have had to be treated with antibiotics on at least 3 occasions. (Just a sidenote, I also have Multiple Sclerosis.)

    In any event, for the first time ever, Cyrus became sick the week of February 6, sneezing 2-3 inch long clots of blood out of his nose. This happened seeming sudden and went on 3 days in a row, then subsided 3 days, then started up again. I thought maybe he was having a sinus infection, even though he was eating normal and acting normal, other than the bloody sneezing. He has always sneezed a bit here and there, but nothing like this before. His one nostril under the left, removed eye is more open than the other. I assume that might make him more susceptible to sneezing.

    I took him to the vet Feb. 18 after a week and a half of off and on again bloody sneezing, and he was given Convenia (due to him being a biter and the inability for me to safely medicate him). He was also given Baytril and Dexamethasone shots. It took a large vet to safely hold him down and another to give the shots. And believe me, he was hissing mad afterwards! Once we got home, he was more docile and actually did not sneeze again for 2 days. However, a few days later he became very lethargic and was not eating very well, and started having sneezing fits. He gets fed one can of soft food a day, broken down into portions, and has a bowl of hard food always set out to supplement and help keep his teeth healthy. He normally Loves his soft food, but he was not finishing the smaller portions I was now giving him, and even left some of his plates not touched at all. Before, even while sneezing blood, he acted normal in every other way, being active and eating heartily.

    I got on the internet and looked all these drugs up and was not happy at all with what I saw about the Baytril or the Convenia. I became very concerned about both medicines and with his health seeming worse. A few days ago he started sneezing so bad – 10-15 times in a row – so that he could hardly catch a breath. He also had developed a very stuffy nose and is “whistling” all the time when he breathes. His one eye has started running and is pinkish around the rim. He is a white cat and this area is usually a very pale to white.

    I took him back to the vet today, 2/27/17 and at that examination I expressed my concerns over Baytril and Convenia and asked that they use alternative antibiotics. This vet (same clinic, different and more mature doctor) agreed with the concern over the Baytril, but advised that due to his biting trouble, he felt that Convenia was best for his condition, and now that it has turned into a full-blown upper respiratory infection, it was important to give him a second dose, along with a longer lasting steroid (Depomedrol) and a vitamin B12 shot. He had sneezed once while there and the vet was able to see that the “snot” was cloudy yellowish, so he felt the infection needed to be treated another 10 to 14 days.

    At this visit, I also saw that he has lost 1 pound, going from 15.20 to 14.14 pounds in 9 days. To be honest, on the first visit there was no discussion or warnings about the uses of Baytril or Convenia. At least on the second visit, this doctor did agree with my concerns. But he still believed that the second shot of Convenia was a must in this situation. In addition, he gave me some Viralys supplement that he wants me to give him to protect from Feline Hepatitis. When we got home, kitty was hungry and did eat a decent helping, but he is very mad at me and ran off and hid under our bed.

    Was it wrong for me to let them give him another shot of the Convenia just 9 days from the first shot? Should I be concerned? Does that double the chance of danger? I don’t have an exact dose amount shown on the bill, it simply states “Convenia injection 0-16 lbs”. I don’t want anything worse to happen to my baby. This is his first ever cold in 7 years of life, so I suppose that is good. Also, there is no chest congestion, so the infection hasn’t moved into his chest. We are supposed to go back in 10-14 days. Any advice you can give would be wonderful.

    • I’m sorry it took me so long to get back to you. Cyrus’ story was so long I had to wait until I had a day off to read it all and respond. Let me answer your last question first: “Does that [giving the second Convenia injection] double the chance of danger?” Yes, but the good news is that since the chance of danger was near zero from the first injection, and two multiplied by zero is still zero, you should have no worries. Notwithstanding wild internet stories about both drugs to the contrary. I’ve used these drugs for years and years and years. There is one specific circumstance in which Baytril, and other fluoroquinolones, should not be used, and your kitty doesn’t fit that contraindication, so you have no pharmacological worries. As stated above, I used Convenia by the “gallons,” and the only problem I’ve ever had with it was a single, classic case of allergic reaction, which responded to standard symptomatic therapy. The combination of cefovecin and Baytril is dynamite. We combine it with several other antibiotics, too, when the case warrants it.
      What worries me, however, is if the discharge you were seeing was truly blood, the problem may not be infection only. If it recurs, (and it may never, we hope not!) I’m going to ask you to encourage your veterinarian to be aggressive with his diagnostics. Doing so will require heavy sedation or general anesthesia. A Feline Leukemia Virus and Feline Immunodeficiency Virus test (note that there are three links there, each taking you to a separate post to read) will be indicated, along with at least two X-ray views of his skull and sinuses. It is possible that your veterinarian may refer you to a board-certified veterinary internist for this workup, although most general practitioners can do all of it.
      I only say “if” because a very few red blood cells mixed with fluid, serum and/or pus can make a very red solution look like “blood,” when, in fact, it is only blood-tinged.
      Viralys was dispensed not to protection against hepatitis, a liver inflammation, but herpesvirus, a common infectious agent of cats. It is used as a non-specific immune system stimulant. Many of our patients are on it. If Cyrus’ doctor has recommended that he stay on it permanently, heed his advice.
      Now, let’s see about getting you some safety. Your veterinarian may already have a relationship with a board-certified veterinary behaviorist, but, if he doesn’t, Dr. Kenneth Martin (click here to visit his web site) can work with and through your local doctor to give him and you advise on medication and other therapy. Unless you live in or near Austin, TX, where Dr. Martin practices, he won’t be able to help you directly, but can work through your local veterinarian to help Cyrus improve his behavior.
      I hope that Cyrus never has a respiratory issue or nasal discharge again, and that you can team with Dr. Martin to make Cyrus a safer and more enjoyable pet. Please do write back and let us know how things go from here. Best wishes, Dr. Randolph.

    • I once had a cat that would bite and even fully attack me. He had hyperesthesia, which was treated with Prozac. Another symptom of this condition is the skin twitching on his back and flinging his head around and licking his back aggressively, one leg stomping really fast repeatedly on the floor while sitting, and just generally aggressive behavior. Strange thing is around children and birds he was totally the opposite. You could try one of those plug in pheromone diffusers that calm cats.
      I have also heard that it is possible that excessive sneezing can be caused by a cat getting a blade of grass caught up in a sinus passage. I heard that it has to be removed somehow.

  19. Can convenia cause long term effects say pancreatitis ?

    • Not in my experience, and I couldn’t find any mention of the pancreas in the package insert. A free call to Zoetis Customer Service would be appropriate, though. Thanks for reading

    • Dr. Randolph what are the side effects my cat had a tooth extracted and he was injected with this when can I expect my cat to be up and running around he is going to the bathroom on time and he is drinking water he’s not eating fully but he is drinking the juice out of his soft food he was at the vet for 4 days he’s now at home. he was very stressed out at the vet & asked if we could take home now. today he looks like he’s back to normal but he still laying around. What should I be looking out for. Is this normal for a cat that’s had a tooth extracted to be so tired?

      • The only side effect I’ve ever seen in a patient administered Convenia was allergic reaction to cephalosporin. That dog responded immediately to treatment and experienced no further ill effects. Having not examined this patient all I can provide is observation based on what you’ve written and what I’ve experienced in hospitalized feline patients with extractions. Given that limitation, I suspect your kitty is tired from the combination of general anesthesia, oral surgery and being away from home several days. You should watch for evidence that he continues to eat and drink, and, if he fails to do either for 24 hours, he should be seen. If the lethargy persists for more than a few days, I’d make an appointment with the doctor who performed his procedure for a medical progress examination. Thank you for reading

    • I have a dachshund that continually gets a rash of sorts on his belly and chest. Our first vet said the convenia shot is the way to go and that we could treat 3-4 times a year if required. This vet has now moved back home (miss him dearly – he was the best). The new vet says we cannot continually give the convenia shot. She has recommended Apoquel. This does not seem to help, so i begged for the convenia shot that we know works. She is now suggesting we see a dermatologist. Yikes!! Is it safe to administer the convenia shot 3-4 times per year? Any suggestions on medications to treat recurring rashes? Any assistance would be greatly appreciated.

      We live in Winnipeg, Manitoba in Canada and we had originally thought it was a spring / fall allergy to falling leaves and snow mold. Now we are just confused as the rash has occurred at other times as well.

      • Your “new” veterinarian is trying to get to the root cause of the problem. Skin doesn’t become re-infected repeatedly for no reason. Giving antibiotics over and over again isn’t solving the underlying condition that’s allowing the infection to recur. I’ve written several pieces in which I’ve discussed the advantages of seeing a board-certified veterinary dermatologist. You can click on each of these links to read some of the articles: one, two, three. Sometimes pet owners have to travel a long way to see a specialist, but it will be time well-spent and will pay dividends for the quality of your pet’s life. Thanks for reading

  20. Dr James Randolph
    I have 7 rescue cats that are indoor w/a large enclosed outside deck and many home made play towers and toys to keep them happy and occupied. My 7th rescue was a 3 year old semi feral male tabby(Bully)”cause he defended my house and his territory against all other strays. Bully was out in the brutal cold all winter, until finally I caught him and brought him directly to the vet for spaying and all other necessary and advised treatments. The one main concern was a large wound on the side of his neck that was there for at least a few months. An obvious fight wound. My Vet ran test and found he was FIV positive. Bully seems to be on good terms with the rest of the feline gang, so i decided to take the risks and keep him despite his illness. The question now is my Vet has prescribed two things: Gentamicin sulfate 2x daily on wound and a injection of Convenia once every seven to ten days for the rest of his life. I went to a second Vet who stated that this was not needed and to just keep a good watch on my cats health with a well balanced diet. Please what is your opinion on the Convenia and its life long administration.

    • I am inclined to administer medications only when my patients need specific medications for specific conditions. Thanks for reading, Dr. Randolph.

    • I have taken in 2 cats with FIV and neither of them had to have convenia injections on any regular basis for the rest of their lives. Even though they were positive for FIV, they were not actively affected by it and lived normal lives. I only found out that one of my cats had FIV in old age when he was being diagnosed with cancer and the FIV result came up in one of the blood tests. The only time they needed convenia is if they developed an abscess after being scratched by another cat or something like that, and all that was required is 1 injection, and maybe 1 more if the first injection doesn’t clear it up. I’m not a vet but I don’t see any reason why a cat would have to be continuously given antibiotics.

  21. My girlfriend and I noticed our puppies eyes were getting swollen and scheduled an appointment with a vet that gave our pup a Convenia shot. It’s only been 2 days so I don’t expect any results… yet. I want to know if there are any eye drop solutions or home remedies we could try to make the swelling go down a bit and would it be safe?

  22. My cat has had an anti imflammitrey and long term antibiotics injections also had a tick removed from him.that was nearly a week ago but now his hardly drinking at all losing loads more weight then before the injections,wont eat and if he does try to eat he throws it up.?

  23. Hi,
    My cat got injectors with lost lasting antibiotics for blood in his urine (suspected bacteria infection).. Where would the injection site for this drug be administered? Cause he’s come
    Up in a massive bruise lump on his tummy where they shaved him (to ultra sound him I guess).
    He’s 6 hours after I took him home, he had pooed all over himself, and it looked like blood in his poo.. It’s been 24hours now and he is a very tight stomach, and He keeps shaking every now and again.. I’m unsure if I should just try and nurse him through this or take him back to the vet?
    Kind regards

  24. Yesterday, we took my cat to the vet. His diagnosis was inflamed gums and stomatitis and (maybe) FIV – the test came back so light that they said he may fight it off (?)
    They gave him Convenia at the office and metacam for me to give at home for a few days. I was expecting to see *some* improvement today, but now his cheeks are swollen and he’s been asleep all day and has only eaten a few bites of food and hasn’t drank any water at all (although they did give him fluids late yesterday)

    The office is already closed and I’m wondering if it is normal or if I have reason for concern. His cheeks were not swollen yesterday at the office, this has occurred during the day.

    I appreciate any help. Thank you

    • Stomatitis in cats can be a perfectly horrible disease, with some cats requiring extensive oral surgery to resolve the condition. I would certainly suggest that he see his doctor again tomorrow. Unfortunately, I can’t shed any light on the swelling problem, having not seen the oral cavity myself. Is there, perhaps, an emergency hospital he could go to? If he’s only sleeping and not eating, that problem might be OK until tomorrow, but there is no way for me to be sure. Thank you for reading, Dr. Randolph.

  25. Sir good day. I have 10 months old dog. He has a fever for 2 days, he doesnt want to eat and drink so i called a vet immediately and vet gave antibiotics to my dog through injecting his left leg. After 20 hours, my dog has swollen in his left leg after injecting this antibiotics and again he doesnt want to eat and drink. What should i do?

    • Juliete, your dog will need to see his veterinarian again to determine the cause of the swelling and the cause of his ongoing fever and appetite loss. While it may simply be too soon for the antibiotic to have controlled the cause of his fever, the leg swelling is a greater concern and needs to be addressed right away. Thank you for reading, Dr. Randolph.

  26. This antibiotic is an absolute miracle hands down!! It literally saved the lives of 2 of my beloved dogs. First situation was related to my 14 year old shih tzu who developed an intestinal bacteria, likely from tooth decay. She was within minutes of death, rushed to emergency clinic for rehydration and antibootics via IV. She survived the night but was still likely to die. As the emergency clinic only operates over night, i transfered my dog to my regular vet who administered this miracle antibiotic shot, and within an hour, literally, she negan to come back to life, and by the next day, she was 100% well again. That was 2 years ago, she is 16 now and touch wood…perfectly healthy.

    The second situation was related to my 11 year old yorkie, and pretty much the same experience as above. Thang God for this antibiotic!!! Particularly if giving anything orally that causes dog to throw up. I have since had any/all rotten teeth extracted and remaining teeth cleaned. I brush daily and take them in for vet dentals every year. IF YOU WANT YOUR DOG TO HAVE A LONG HEALTHY LIFE AND ELIMINATE BIG VET BILLS, KEEP THEIR TEETH CLEAN

  27. My 2-year old cat was injected with Convenia yesterday for an eye infection. We brought him back today for some bloodwork etc. and they found out he has a heart infection as well. They injected him with 2 other antibiotics. Is this common practice?

    • Sorry, Jade, but I don’t have nearly enough information to go on. Can you tell me the nature of the heart infection? Using antibiotics in conjunction with one another is not uncommon for a synergistic effect. Thanks for reading

  28. My 10 week old kitten has large sores/lesions that keep popping up and then healing. MOst are on her neck/ear/back area. The breeder thinks it is from mom over-preening her due to her being a singleton and has developed a bacterial infection. Vet thinks it could be demodex (parasitic). I am leaning more towards the bacterial infection for several reasons, one being that none of her other cats are infected and two because she’s not itching and the cytology showed no signs of this. Would giving convenia injection do any harm? I am thinking to try this route and if things don’t clear then getting a skin scraping to test for mites. Thanks.

  29. Convenia has cured my cat’s diarrhea twice. Originally his long time [possibly IBS] caused an anal abcess/wound. First round of shots cured abcess and diarrhea. This first time, left him mildly [urine only] incontinent but I learned to accept that. 2 years later, He started having explosive diarrhea again, gave 1 convenia shot, now has bloody urine and an overactive uncommon [for him] need to urinate. He squats everywhere and every few minutes- sprays, sometimes reddish, sometimes not.
    He is 10 years old, 12 pounds, Siamese/manx mix. No tail has been suggested reason for issues since kitten.
    any thoughts ?

  30. My (almost) 14 year old cat developed a large abscess in her mouth/face overnight and received an antibiotic injection this morning. How long would it normally take before I can expect a change in the abscess? It looks like it hasn’t changed size in about 12 hours and it (possibly) more solid than it was before. The vet drained a small amount of fluid this morning, but it much.

    • Medical cases aren’t prognosed according to the medication(s) used, but by the condition and its severity. With only a “small amount” of discharge being removed, it’s more likely that your kitty has cellulitis than an abscess, meaning the infection is spread among the tissues, whereas an abscess has most of the infection contained in a pocket. Abscesses tend to respond faster to treatment than cellulitis, assuming they are well-drained. As for prognosis and timing of improvement, you’ll have to ask the doctor who examined and treated your kitty. I’m simply not there. Thanks for reading, Dr. Randolph.

  31. my cat had a convenia shot 14 days ago still not well can he be started on amoxillin

  32. My cat is 9 years old, 8.8 lb neutered indoor cat. I adopted him from a vet when he was 2 years old. They tested him for the Leukemia, and feline aids virus and he was negative.

    A year and half ago I noticed he was not eating and losing weight so I brought him to my vet. Upon examining him the Dr. noticed that it was his teeth that were very bad, and had
    to extract 6 of them. After he was his normal self.

    2 and ½ weeks ago we noticed the same thing and brought him to the vet again. Around his upper back tooth was very red and when the vet touched it he was in pain. My vet said that
    was probably the cause of him not eating, but wanted to take blood work to be sure. His blood test came back very good, his vitals were all stable overall a very healthy cat.

    My vet told me that he would give me a two week antibiotic injection, and 4 anti-inflammatory pills. I was told that it would be easier to give him the injection than to give my cat a pill every day.
    I was never advised of the side effects it could have.

    My cat was perfectly fine previous to the injection. He was running, playing doing all the things he loved doing. The following morning Tuesday after the visit with my vet my cat was lethargic, he did
    not want to do anything except sleep. I called my vet he said it is normal he could be sleepy. Wednesday I was really worried called my vet and saw him that very night. They took more blood work
    and what came back I cannot believe

    White blood cells 2.4
    Red blood cells 5.5
    Hemoglobine 8.8
    Platelets 48

    I was told he could have cancer…

    We spoke to my vet again and asked him why was the blood work normal on Monday and Wednesday after taking the antibiotics the blood work was bad. We asked him could it be
    what you injected him causing everything he became very defensive…

    Up until yesterday my cat has been getting worse and this weekend was really bad. He did not want to get up or eat I had to pick him up and bring him to his food, water, and litter.
    very lethargic, hind leg weakness, he seems to be sensitive to the touch for example if I touch his ears he shakes his head. We feared for his life last night.

    This morning when we woke up my cat was already up on the kitchen counter, we poured food into his bowl and he jumped down and ate his food, drank water twice, went
    downstairs to his litter, and came running up, no longer lethargic, some minor weakness in his hind legs. His ears would move when he heard sounds which he has not done since before
    the first visit to the vet. He seems 80% better.

    So my question is good it have been the Convenia causing everything that was happening to him?

  33. Two days ago I took a kitten off the street, to foster. He is very skinny and was somewhat lethargic. I wanted to foster him and then release back to his family. He seems about 5 weeks old. First day at my home he didnt want to eat, but drank some fluids. He had diaorheea. Second day (yesterday) took him to the vet, he had his ears cleaned and antibiotic shot for mites infection, oral vitamins and was de-wormed. Kitty felt better after that, even ate a little by himself before the night sleep. This morning got up and asked for food, ate a little, drank a lot of water, still had loose stool. Midmorning he grew very weak. I took him back to the vet who diagnosed URI and gave him a shot of antibiotic + a shot of vitamins. Since then Ive been feeding baby food with syringe every 2 hours or so. He is completely floppy and just sleeping. He has fever, but the vet said he doesn’t need any panadol or other pain med. Tomorrow he@s due for another shot of antibiotic. I’m wondering if there is hope in situations like this…. he is so weak and still hot. I’d rather be prepared and consider putting him down then watch him go slowly from dehydration and pain.

    • Only you and the doctor treating your kitten can make that decision, as we simply don’t have access to the patient or sufficient information to help with that call. I’m sorry we couldn’t be more help. Best wishes, Dr. Randolph.

  34. Can Convenia be given along with Orbax? My precious kitten was spayed 2 weeks ago and was seen for an infected draining incision just 3 days post op. Was on Clavamox and Orbax since then. In follow up yesterday with the veterinarian we stopped the Clavamox and he gave her a Convenia injection and said to continue the Orbax and will recheck in 1 week. Also removed sutures and put staples in as she isn’t healing as he thought with the antibiotics. Been so worried and yesterday was the 4th time into the veterinarian in 2 weeks as it was 2 weeks to the day yesterday of her spay surgery. Just love my little girl , sweetest little thing ever. Feel terrible for her going through this after such a routine procedure. Can’t wait to get the cone off!

    • Kelly, Orbax and Convenia have an excellent synergistic action, giving an even broader spectrum of bacteria-killing than either antibiotic alone. Not only are you frustrated by complications such as these, it’s terribly frustrating for veterinarians, also! We like our patients to heal properly and quickly, and dislike these side trips as much as you do. Please stay in touch. We hope your precious little baby is completely mended soon.

    • Brought a 4 month old kitten from a shelter. I noticed he was sneezing all the time, runny eyes and nose. Took him to our regular female veterinarian. He was given a shot of Convenia. Within two days he was a normal kitten running wild! We have our beloved Callie cat who has now contracted this same upper respiratory infection from the shelter cat. Got her in to the veterinarian but was unable to see our regular female vet. I mentioned to the new male veterinarian that our regular veterinarian had given the Convenia shot and that our cat is better. He didn’t want to give an antibiotic injection. Instead he gave Dexamethasone injection on Monday, and she is getting progressively worse…not eating, her fur doesn’t look right, she is very lethargic and is sneezing much more. She doesn’t look good. We are also treating her eyes with Erythromycin ointment. I feel like she is going downhill fast. I want to make another appointment with my regular veterinarian. Its seems to me that if the kitten got better after the Convenia that maybe my other cat should receive the same thing.

      • When you call to make your appointment, specify which doctor you wish to see. Your “regular” veterinarian may be more in tune with your wishes, having had a longer relationship with you. Please write back and let us know how both kitties do. Best wishes, Dr. Randolph.

  35. My cat had an anal gland abscess and was given Convenia. Three days later he is exhibiting respiratory infection symptoms, sneezing and clear watery eyes. I called the veterinarian and they said he does not need to be seen as he is on Convenia. Am I being paranoid or should I have cause for worry? Wouldn’t this have knocked this out versus brought this on if he was coming down with a respiratory infection but not symptomatic?

    • It is not unusual for our feline patients to develop secondary illnesses when stresses occur. These may be conditions that are hidden from view when the patient is well, but, when the immune system takes a dip, that condition becomes clinical. Nowhere is the preceding statement more true than in the case of Herpesvirus respiratory tract infections because the quiescent Herpesvirus causes no problems while it is dormant. If the immune system becomes taxed by responding to a disease process, such as an abscess, the Herpesvirus (eg: Feline Rhinotracheitis virus) proliferates. Viruses are not killed by antibiotics, therefore, while the Convenia can kill secondary bacterial invaders, no antibiotic can kill a virus. If your kitty isn’t making positive progress by Monday, check in with his veterinarian again. Feel free to write back and give us an update.

  36. Patrick Sutherlin Sr
    Patrick Sutherlin Sr

    I have a Red Heeler that about 10+ years old, spayed and chipped. Question: She has a skin condition that every time I get on spot cleared up another shows. It’s a rash looking condition, no infection, just gets inflamed and secretes small amounts of fluids, I’ve washed her daily, treated Her with Peroxide, Neosporin and 40% Zinc oxide with out results of it coming back immediately in a different spot. The previous spots have black skin and the hair starts to return, but it will show up again close to where it was previously. Small spots, dose not spread, just small spots. What can I treat it with?

    • I beg to differ, Patrick, when you say, “It’s a rash looking condition, no infection.” Actually, there is no way for you to know if it’s infected, or not, just by looking at it. Often we think of infection as being associated with drainage, but pyoderma, infection of the skin, rarely drains. Your pet needs to see a veterinarian. There is no way anyone can make a correct diagnosis without a thorough examination. Without a correct diagnosis, there is no way the treatment advice is going to be correct. Please let us know what her veterinarian finds. Best wishes, and thanks for reading, Dr. Randolph.

  37. I took my 5 year old cat to the vet 3 days ago because he was very lethargic, didn’t eat or drink, and had diarrhea. Two days before that, I had my daughters nursery painted and I believe it was the paint fumes that sparked his fever. When I took him to the vet, he had a fever of 105. They gave him a shot of Convenia, and a 72 hour pain control injection. They also gave me two cans of “prescribed” cat food. When I brought him home, he ate a little bit right away, and he was feeling good and wanted to even play with his favorite toy. I think the pain control shot worked wonders right away. But now, three days later after the shots he has the same symptoms. He hasnt ate, still has diarrhea, he has been drinking a little bit of water, but vomiting orange liquid or dry heaving. But he’s still lethargic and hides underneath the couch all day. Which I’m worried about, because I can’t monitor him and see how he’s doing. My question is, is this supposed to be happening, if so how long will this continue? When will my cat be back to normal? It’s only been three days, but I’m worried sick.

    • Fumes can’t cause a fever. Typically we expect toxins to lower body temperature, not raise it. The diarrhea is a concern for me. You didn’t list a medicine specifically for diarrhea. Cats who don’t eat can develop complications quickly. I would be on the phone to the veterinarian who treated him, outlining his current status and my concerns. Please keep us posted on his progress. Thanks for reading, Dr. Randolph.

      • Odd that he would suggest it was the paint fumes that triggered the fever then. He is an indoor cat, but about 3 weeks ago he got out for 3 hours, I’m wondering if he didn’t catch something then? I can’t call the vet today since they are closed, but Oliver is shockingly being active, not hiding under the couch. Seems to be getting a little bit of his energy back, even sitting in the window getting fresh air. No vomiting yet, either, and he hasn’t used the litter box so I can’t tell if he still has diarrhea. No medicine was given for that, just the antibiotic and pain reducer. This morning he drank quite a bit of water, but still isn’t eating. He is quite picky about what he eats, so maybe he isn’t fond of the prescription canned food. Anyway I can get him to eat it, or can I try to feed him his usual favorite – friskies chicken in gravy, or would that upset his stomach? The vet told me to stay away from dry food, and his regular canned food for about a week, and only feed him what he gave me.

  38. My cat is not eating or drinking. The vet thinks it is pancreatitis due to what Helen is experiencing. She subscribed a convenia injection, regular fluid injections, cerenia injection for nausea, and pain meds. I am force feeding her to her dislike. She is a little better but not eating or drinking. Her blood panel showed anemia. How long does it take the convenia shot to take effect? She is only 12 years old and I feed her Royal Canaan gastro and hyperalergenic food. Thank you for your help.

    • As for Convenia’s speed, see my response to Lyla, above. However, the speed of Convenia isn’t the driving force of your kitty getting well. Recovery from pancreatitis is, and it’s usually not a condition that heals rapidly. Be sure to ask your veterinarian about feeding, as she MIGHT want her on feeding restriction and/or a special diet while she recovers. Keep in close contact with your veterinarian throughout the condition in case she needs additional treatment. Best wishes and thanks for reading

  39. my 7 yr old female sibe husky was given a shot of convenia 6 days ago, now she’s licking and scooting often. is this a reaction to the shot?

    • Please don’t get sucked in by the Internet hysteria about Convenia. Even if your dog were to have a reaction to Convenia, if wouldn’t involve licking and scooting and it wouldn’t last six days. You don’t mention what she got Convenia for. Was her original problem in the area where the licking and scooting are? In any case, this is a question for the veterinarian who is treating your pet. If she has developed a new problem, it needs to be addressed. Thanks for reading, Dr. Randolph.

      • i was just wondering if maybe the shot had given her an upset digestive system. she got the shot for an infected wound on her paw (though im not certain its working on healing that). i have starting giving her 2 benadryls twice a day and that seems to have settled down whatever was irritating her. i called our vet fri, sat, and today (monday), supposedly the vet is going to call me tomorrow

        • I’ve never seen gastrointestinal side effects with Convenia, although oral versions of its “cousins” are renowned for causing vomiting. As far as the Convenia “working” on the wound, it is very broad spectrum, but its use is limited to killing bacteria (infection). The remainder of the healing process depends on good care, a strong immune system and time for the body to effect healing. I’m sure your veterinarian will be calling soon.

  40. Hi. My dog who has a skin infection and is 12 years old received a dose of Convenia and I’m reading about it and it’s scaring me!!!! The veterinarian didn’t tell me anything about the drug at all-just said how great it is. He also diagnosed the skin by sight. Should I be worried about this injection?

    • Merritt, I can say nothing but good things about Convenia. I use it by the “gallon.” I apologize for taking so long to get back to you, but I’m confident that your pet did fine and that he had no difficulties with Convenia whatsoever. Thanks for reading, Dr. Randolph.

  41. Merritt, I don’t know exactly how all of the hysteria got started about Convenia, but it’s certainly unwarranted. You can search for “___ killed my dog” (or cat), putting just about anything you want in the blank, and get thousands of hits. But, if you read the comments on this post, you will find that I’ve used the drug successfully in untold numbers of patients, without harm. Rest easy, Merritt.

  42. We have a male orange tabby cat who will be 10 years old in Sept. About 9 months ago, he had to have “several” teeth pulled. He has struggled on and off the past 5 years of his life w/ bad teeth, which my vet says happens in about 10% of the cat population, for unknown reasons. He had a very hard time recovering from this surgery (he had lost teeth prior to this surgery as well). In fact, we feel he has never really been the same after this surgery. We took him back in over a month ago, because we noticed he was losing weight over the past few months. We thought at some point it would pick back up, but never did. After taking him back to the vet, they did blood work on him. The results came back several days later that his protein was a little high, and that he was in the beginning stages of kidney disease. After examining him, she said his gums looked a little inflamed…but didn’t seem concerned. After another month has gone by, he is still not eating well (and we’ve tried just about everything under the sun, including wet cat food, ahi tuna, canned tuna, chicken, salmon…etc). While he eats VERY small amounts at one sitting, he generally also will not eat the same thing twice in one day. I took him back into the vet this past Thursday morning and had them look at his mouth again, as this is the way he acted when he needed to have them pulled last year. She said the canine tooth he has left looked abscessed, but she said the tooth was not loose. So she gave him this 14 day antibiotic injection, and scheduled him for this Monday (tomorrow) to have the tooth pulled. She also said that if he started eating better over the weekend, that we could cancel the surgery if we wanted to. So they are waiting to hear back from me first thing in the morning now. They are also going to run more blood work if they do the surgery, to see if more is going on w/ him. I hate to have him go thru this surgery again for one tooth, knowing how hard it was for him to recover from the last one. If this tooth is removed, he will have about 5 teeth left, and I hate to see him go thru surgery every time a tooth goes bad. My question (after all of this) is, being that he was given a 14 day antibiotic, if we waited another few days, might he show some improvement? So far we’ve seen very little improvement in his eating, and right now this is our main concern. He can’t keep losing weight at this rate. To make matters worse, we will be traveling most of the next month, so I am very scared about getting into all of this, and something going wrong. I have had this baby since he was 4 weeks old, and I just can’t lose him this way. I think more than anything, I would like to buy 4 – 6 weeks to make a decision on another surgery. We would be back from traveling then, and would be here for him non-stop if he has issues. His appetite seems to be ok, he begs for food a lot. He just won’t hardly eat when we put food in front of him. He does drink a fair amount of water, but vet said he was dehydrated last Thurs, so she gave him some fluids as well. I know my sweet kitty can’t keep going at this pace either. At this point, he is down to 13 lbs, 1/2 the weight he was 9 months ago. I know you probably can’t provide answers to this in depth case, but again, my real question is on the antibiotic, and if it is likely things might improve for him, given a few more days and that it was a “14 day injection”. If you have any other inklings or suggestions regarding his case (as you know it here), I would very much appreciate this as well. I am really using this forum as more of a 2nd opinion regarding my concerns, rather than a plan of action going forth. I am just stumped as to what to do, come tomorrow morning. Today is our last day to try to get this figured out, and I feel like I am stuck between a rock and a hard place. Thank you in advance for your feedback.

    • Well, Dana, you’re right, there isn’t a lot I can offer. Between not having examined your kitty, nor having looked at his lab tests, I’m pretty limited on what advice I can give. Kidney disease can have a lot of parameters, so we don’t know what all of the implications are of those test results. You might ask your veterinarian if she feels a referral to a board-certified internist and/or a board-certified veterinary dentist is warranted. If she feels she has a good handle on his problems, she will say no. If she feels it will help him, she will encourage a referral. Please write back and let us know how your kitty progresses. Best wishes, Dr. Randolph.

  43. I have a four year old neutered cat, Bandit, and e has an open sore on the left side, very close to where his tail joins his back side. It,s been there a while. I didn,t notice it for some time, for his hair covered it. In time, after noticing him twisting around to the area, i realized he had licked the area so much the hair came out and exposed the wound. It’s bigger than the size of a quarter, fairly deep, and blood red. It’s actually appeared to be healing, as a white looking membrame grew over it. Then, the same thing has appeared aroumd his entire tail. Not a continuous open wound, but sort of like a hit and miss thing. He won’t let me attend to the wounds too long, and definantly won’t allow neosporin to stay on the wounds. An acquaintancet
    he next town is a vet tech, and he mixed up an injectable cocktail of steroid and antibiotic, to be injected in bandit’s rear end after flushing woumd out with a saline solution he provided as well. Then he also gave me 2 large pills, cut in half, 4 pieces in all, to crush and give him one a day three days after the sreroid cocktail. I’m petrified to go through with this, after reading some of the comments on your web site. Can’t afford a vet bill, as my husband left three years ago, and provides no support. Plz help! I LOVE MY BANDIT!

    • Pam, I wish I had a magic cure, but I don’t. If you have a veterinarian you have taken your kitty to previously, and have an established relationship, perhaps that doctor would allow you to make payments over time. By the way, in most states, your “acquaintance” would be in violation of the state’s practice act by treating Bandit without a license, and not working under the direct supervision of a doctor. If Bandit has never been to a veterinarian your next best chance for getting him some treatment is to call various clinics and ask for help. Best wishes, Dr. Randolph.

  44. I’m fostering a kitten who recently sustained an injury to one eye – I think one of my cats scratched the eye. So now she has a corneal abrasion and conjunctivitis. When I took her in to the shelter that I’m fostering her for, they put her on an antibiotic ointment 3 times per day for 14 days. After one week with little improvement, I took her to my own veterinarian who prescribed Orbax and Tobramycin eyedrops. Would Convenia be of any benefit in this situation?

    • Michelle, it’s unlikely that Convenia would help here. Systemic antibiotics are useful when infection is on the INside of the eye. Thank you for taking on the loving, caring task of fostering this baby, and for going the extra mile to have your own doctor look at him. Many times these disadvantaged kittens suffer from Herpes virus infections in the eyes and may require addressing that, if present. Your veterinarian will know. Thanks for reading, Dr. Randolph.

  45. Dear Dr. Randolph, yesterday I discovered Blackfoot in my office under my desk. I thought she was just sleeping, but when I went to pet her, I saw that there was matted fur, all sticky, on her front left leg. The leg and paw were very swollen, too. At first I thought she had been in a fight with a possum.
    We took her to the vet, but were not able to SPEAK to the vet. We picked her up later, and again, the vet was unavailable. The receptionist gave us some papers, with no further instructions. The papers indicate that Blackfoot received:
    “Subcutaneous Fluids”
    Convenia Injection 0-15 lb
    Additional Injection, Feline (nothing else indicated here!)
    Digital X rays, Level II

    She has not had any water or food, nor used the litter box. All she does is sleep and is very listless. It looks like they shaved her leg. Overnight, she actually climbed the stairs and hid in our closet…which we thought was amazing because she is so lethargic and can’t walk on that one leg. We are hoping and praying that she did not go into the closet to die! What can we do? Should we try to give her water with a dropper? I don’t think we should force it but I am so worried about her. We have a call in to the vet and hopefully they will call us back soon. I’m glad I found your blog, thank you so much!!!

    • Elucia, I’m sorry it took me a while to get you an answer. My computer has been broken and I just got it out of the shop last night. As you can imagine, I’ve had a lot of catching up to do. Assuming there were no fractures in the swollen leg, the most likely other problems are abscess and cancer. I assume that if the X-ray they took showed bone cancer the doctor would have informed you. You can read about abscesses by clicking here. However, if there were an abscess there is very specific treatment that must be performed. I would hope you would have been advised about that care IF an abscess had been diagnosed. If Blackfoot is still feeling poorly you must communicate that to the doctor/office staff and she must have ongoing treatment/supportive care. Please write back and let us know how she is. If you cannot get your regular veterinarian to provide adequate care, consider seeking a second opinion at another doctor’s office. Best wishes, Dr. Randolph.

  46. Is it appropriate or safe to give a cat a Convenia shot in the scruff of the neck as opposed to the hip? If I remember correctly, my cat was given the Convenia shot in her neck, and now seems to be having an adverse effect from the shot, including neck pain, lethargy, dry heaves and vomiting after eating, slow movement/slow walking, appearance of general malaise. (She was given the shot because of the appearance of the 3rd eyelid in her left eye suddenly, and a constricted pupil, but without any other symptoms/issues. The vet did see some redness/inflammation at the area of the back left tooth, so the Convenia shot was given). I am so worried the cure is worse than the initial problem, as she did not display anything wrong except the 3rd eyelid and constricted pupil to begin with. I have read so many scary things online about Convenia, and am afraid for my cat’s health/life. (unfortunately, we found out too late from a previous vet’s records that she probably had an adverse reaction to Convenia 3 years ago, but was given the shot in the back leg, and could not walk well/dragged her leg) the next day or two. My question again: is it safe, or worse for the cat to get the shot in the scruff of the neck vs. leg? Could it cause neck pain? A squeaky, scratchy meow? I am worried sick! I’ve talked to my vet, but would like another opinion. Thanks!

    • I believe that subcutaneous injections in the neck region fall within the standard of practice in most areas of the United States. I have a hard time connecting some of the signs you are seeing with a Convenia injection, BUT, they are signs that cause me concern. None of the problems you mention fit a healthy cat, and, therefore, need to be investigated. Anisochoria, unequal pupil size, can be associated with Feline Leukemia Virus (as well as a kazillion other possible problems). You may want to have her tested. Click here to read about the test. Remember, too, that Zoetis (formerly Pfizer Animal Health), makers of Convenia, are happy to help if your veterinarian simply reports an adverse event to them. Click here to read how. And, please post comments here to let us know how she is progressing, what the test results are and what treatments are instituted. Thank you for reading, Dr. Randolph.

  47. My 11 year old cat has been diagnosed as having a low grade urinary infection and Convenia was prescribed. The first injection really helped and she has been far happier since the injection. What puzzles me and concerns me after reading all these posts, is that she has prescribed another injection to be given 2 weeks after the first,(which is now) without any further urine tests being done. How advisable is this? I am especially concerned considering the Convenia stays in the system for 2 months, the age of the cat, and the fact that I was told it was a low grade infection (staphyloccocus schlefii schlefii).

    • On this page, press Ctrl-F (Command-F on a Mac) and type in deep breath, then press the Enter key. The advice I gave Luccianna also applies in your situation, I believe. Then, Page Up and read Lucianna’s reply to me. I am confident that your kitty will be better, and, if he isn’t, it won’t be because Convenia was at fault. If she’s not better in a few days she will require additional testing to determine what contributing factors are in play. Sooner than a few days if she seems a lot worse. Please write back and let me know how she does.

      • Many thanks, Dr Randolph, my kitty seemed fine but I must say once the 2 weeks was up she seemed a little under the weather again. My veterinarian gave her the second injection as my he suggested, and she seems fine again. My veterinarian seems happy that the second injection will do the trick – do you agree or should I have her urine tested again to be sure? (Will it have to be the needle directly into the bladder test or can I get away with catching a free flow sample?). I know it sounds odd – first I don’t want to give her a second injection and now I am asking if I should give her a third, but I just want to be sure she is clear of any infection.

        • Testing after urinary tract infection is crucial, Dale. Click here to read all about that concept. Be sure to click here, too, to read and understand that not all urinary tract inflammation in cats is infection. Hill’s Pet Nutrition has come out with a new form of their classic c/d, which they call Stress Formula. I haven’t written about it yet, but it contains natural ingredients to reduce the stress that is believed to play a part in so-called interstitial cystitis. Ask your veterinarian if this food might be right for your kitty. As to whether to have the urine specimen obtained by cystocentesis or CCS (clean catch midstream), that is up to your pet’s doctor. The fact is, however, that pets tolerate cystocentesis extremely well and it is the best way to avoid accidental contamination of the urine specimen.

          • Thank you so much Dr Randolph. She is currently eating Hills c/d and Hills j/d as she also has bad joints, but I will ask my vet about the Stress Formula. She has been slightly stressed ever since we were adopted by three 3wk old kittens 3 years ago, so that may be just what she needs.

          • I am delighted that we were able to help. Thank you for reading, Dr. Randolph.

  48. Should the pet be monitored after Convenia shot and before leaving vet? I would be concern of a particular pet having a negative reaction shortly after the shot.

    • Maria, I have used untold quantities of Convenia, and I have seen one (1) reaction, which was clearly an allergic response by the way it presented in the patient. The little Cocker spaniel responded quickly to usual allergic reaction protocol with no sequelae. So, if you had nothing better to do than hang out at your veterinarian’s office for 15-20 minutes, that would be an abundance of caution, but otherwise, no, I do not recommend monitoring of any kind, and neither does the package insert for the product. I reported the incident to Pfizer Animal Health (now Zoetis) and they informed me that such allergic reactions are quite unusual with Convenia. Thanks for reading, Dr. Randolph.

  49. Thank you Dr., for this great site. I’d like to share a little history and a few questions, if that’s OK.
    I adopted 2 feral-caught “twin” brothers 12 years ago. They have been my joy. While their gray/white tuxedo markings were identical, one had long hair, and was built like a tank, the other was more lithe and had short hair. And they were inseparable.
    Unfortunately, the last few years have been desperate financially, and I wasn’t able to continue with their check-ups.
    2 months ago, the short hair guy died under circumstances that STILL drive me batty. I noticed he had his 1st claws on each front paw were becoming ingrown. I took him right to a veterinarian, who fixed the claws, gave him an antibiotic, and said he had a heart murmur.
    Within 24 hours he was almost catatonic, eyes fixed and dilated, hiding under a chair and growling. This was fee I could not afford the sweetest indoor cat, so no rabies.
    In the middle of the night I took him in (for an emergency fee I could not afford) and was told without $1000.00 dollars of tests, nothing they can do but try an anti-nausea and pain shot.
    OK I was desperate as he got worse. Found a home veterinarian – she came over, took one look at him and says: “He’s had a stroke, watch, he’s seizing.”
    They gave him a steroid shot, and I’d fed him for a day with the syringe, but he was done.
    He did begin to seize and within 24 hours he’d had 3 massive ones and was dead. Nails clipped on Tuesday. Dead Sunday at 7 AM. Thank God for the home veterinarian, who was on the phone with me much of the time in the last hours.
    So, I’m still spinning over that, and last night his brother stopped eating, is weak, listless. Took him to the home veterinarian’s hospital and the veterinarian was very understanding. Gave him Convenia and we’re waiting for blood tests.
    I’m feeding him baby food; he won’t touch cat food.
    I’m praying this can’t be happening again so soon.
    Thanks anyone any thoughts on any of this. It’s a bit unreal for me.

    • What a sad story, PJ! You have done your best and you “bought” some really good quality time for these two, who would otherwise have lived the miserable existence of a feral cat (not that they know it’s miserable, they are probably just happy to be alive, unlike us humans who would wallow in our misery.). Unfortunately, as your emergency clinic pointed out and your house-call veterinarian supported, without appropriate diagnostics the best we can do is perform a thorough physical examination and, using the information provided, create a treatment profile based on that. We must recognize that, in many cases, more information is needed to make an accurate diagnosis and proceed to effective care. Sometimes such symptomatic treatment is effective. Sometimes it is not because we could have had more specific treatment if we had the input of more information. So, I have the information you have provided, but the list of differential diagnoses is so long for those symptoms that you’ve given that it is impossible to narrow that list. I wish I could help more, but I would have to be there where your kitty to examine him, at least as a beginning. Please keep us posted on his progress. Best wishes, Dr. Randolph.

      • Thanks Doc. This morning the vet told me his bloodwork confirms his kidneys are failing.He said barring a transplant we have days or weeks. He’s only consuming cat formula today.I’m going to keep watch and have the home vet come when it’s time. Thanks again.

  50. I have a cat who needs tooth extractions due to gum disease. She is 12-13 years old. I tried giving her a liquid antibiotic and was able to get 2 doses per day down her for 7 days and one on the 8th. Then she started hiding, and I could not finish the dose. Can she get an injectable antibiotic before and after her surgery, so I don’t have to try to give her anymore myself? I accidentally got some in her eye one time, because she fights me so hard, and it’s been swollen and bleeding off and on for over 3 weeks now.

    • Only the veterinarian treating your kitty can answer the question of what medication your pet can have. However, if he uses Convenia she would not need an injection both before and after her dental procedure, because one injection keeps therapeutic levels of antibiotic in her systems for 14 days. If your pet’s doctor is not yet using Convenia, he may be able to obtain enough for your kitty from a nearby colleague.

  51. My cat had PU surgery a week and a half ago, since then, he obtained a bladder infection (UTI) (three days ago) and was given a shot of Convenia to clear it up. The shot worked very quickly for him – mind you, he was back at the vet’s less than 24 hours after we noticed the infection (blood in urine, frequent litter trips etc), so we caught it fairly early. I noticed improvement in his blood-urine and peeing after a few hours of the shot (he had quite a bit of blood in his urine before and it was greatly reduced within 2 hours). He is still recovering from the PU surgery so he is confined to the laundry room with light coloured sheets around so we can monitor everything – that made it reallllllly easy to catch his infection quickly and monitor that as well now.
    My worry: the Convenia reduced the blood in the urine VERY quickly. Is this normal? I guess after reading all these crazy stories about Convenia, I started to wonder if perhaps he is becoming anemic and that’s why the blood in urine reduced so quickly. Am I being crazy?? These bloody horror stories on the internet are enough to drive any pet-mom crazy.

    • It’s certainly not impossible for your kitty to become anemic from blood loss. And, it’s a danger worth watching. If he is anemic you will notice a proportional decrease in activity level and appetite, possibly faster breathing. We perform perineal urethrostomy on patients whose bladder disease cannot be managed medically. Those patients inherently will be more likely to develop blood in the urine, with or without infection. It takes so few red blood cells in even a large quantity of urine to make it look bloody, that it’s unlikely anemia would cause a change in the observable level of color. If in doubt, ask your veterinarian to perform an in-house test called “microhematocrit,” which will quickly tell him the percentage of the blood that is red blood cells. If that number is too low, a diagnosis of anemia is made. He would then seek to find the cause of the anemia. Continue to be vigilant but do not worry yourself to distraction. Keep in mind that 64% of the medical information on the Internet is either outdated, or outright wrong.

      • Yes it was after his 4th blockage that our vet had suggested the PU surgery, as he was on the proper diet and still managed to get blocked up – the week of his surgery he had 2 blockages back to back in 24 hours so we had decided that the best course of action for him was the surgery. I hate seeing him in so much pain, not to mention, being catheterized time and time again isn’t pleasant.

        I am monitoring closely anyways since he is still recovering from the PU surgery. Its been two days since the convenia shot, he is eating just the same and will get up to use the litterbox or eat no problems. He isn’t so active, but hes never been a really active cat, and to be honest there really isn’t much to do in his recovery room – we were trying to cut back activity so he can recover from the surgery properly.

        He has his check-up on Thursday for the PU, so providing we don’t have any issues until then, he will be getting a urinalysis and blood test then. I will bring up the ‘microhematocrit’ to them just for my own peace of mind.

        Thank you for that bit of information on anemia and how there would probably not be a huge noticeable difference in the blood-urine level. That relieves me! I will still continue to monitor him closely but lets hope he doesn’t need to go back to the vet until his check-up on Thursday!

  52. Hi there, I am treating a very complicated case. I have a spayed female young cat=age unknown=I have had her for about a year. Her present conditions: asthma and allergies and floating patella in right knee and some in left knee but not as inflamed when it acts up medications: dasquin daily, flovent twice daily, lysine treats and albuteral as needed My question is she has been battling several issues since march 15. We or rather I made the poor choice to show her in the catfancy show in rutland vt but she got very stressed. That weekend she wouldnt eat enough. monday we were home and she still wouldnt eat-she acted normal, drank water, no sneezing no Gi upsets.. tuesday she still wouldnt eat., I then noticed her back end collapsed and she struggled to stand up=I dont know if it was because of the known knee issue, inflammation from being in a cage for 2 days, all the handling back and forth cage to judge etc or just weak from not enough food. I managed to get some treats into her and tuna but very little. Tues night we went to the er. She was diagnosed with pain in knee and think not eating from pain. then when drew blood we had a hard time stopping the bleeding. I was holding her after bloodwork and she bled out of her right leg. I of course applied pressure with towel and hollered and they said it took 3 to 4 min to stop the bleeding.. so we originally were go to treat: subfluids for dehydration, pain meds for obvious pain and lame leg and just try to get her to eat. I asked for antinausa med like cerenia/zofran and they refused. said to use pepcid..ok so now that the bleeding issue reared its head they talked me into leaving her overnight for iv fluids because they wouldnt do subfluids with risk of bleeding..and of course once the iv is running they can do yes I opted for buprenex, pepcid via intravenous, and electrolites..the bloodwork they did came back low now here I am crying thinking I need to put her down because I know this is not a quick fix..but I calmed down..let them take her… So here it is april 7th..that day was march 18th. She ended up staying for 2 days=they got a bone marrow aspiration to make sure she is making platelets etc=yes all normal, did ultrasound on spleen/organs=normal, clotting time test-normal, sent off another bloodwork for manual count of platelets and compplete cbc=normal=no she is NOT anemic. her hemocri is 37-41. they started her on pred on wed nite after bone marrow sample incase immune system mediated=we did 5mg wed march 19th, 10mg thur and fri. fri nite they called said tests came back normal for 184,000. ?!? the test in hospital only registered 5,000. they took some on a slide and guessed maybe 30,000 but definately lack of platelets.
    they told me to take her off the pred. do 2.5mg sat and sun and mon. I forgot to give her mondays dose. Then i was supposed to do wed and fri 2.5mg and I felt she was getting icky on the pred so i stopped it=meanwhile she WAS eating better during that time but still in pain. we did the buprenex up to tuesday march 25? I cant remember..they did give me mirtazapine for appetite stimulant as it was starting to lag after the pain meds.. so then on march 30 we went BACK because she was breathing superfast. That day I DID give her a dose-1/4 tab of 15mg and I did see her eating within an I thought we are done..until the breathing was at 60 a we went in did xrays-no fluids no nothing other than her classic asthma. she was hydrated and wormy squirmy meowy=they think side then the next few days went ok, still limp but not bad..she was eating on wednesday 26 so i opted not to do the mirt. thur morning she didnt eat=so I tried to give her more=she spit it out, i crushed in food and gave it..bad mistake..poor cat. so i called the er to get cyproheptadine and they did. When i got home she was lethergic so I called and asked them if i should give cypro=yes and I did..within an hour she came this normal? so anyways i didnt give it frid april 4th because she was doing well. fri nite she had bad diarea. sat morning april 5th VERY lethergic. I got her to eat baby food..but couldnt get pill in. she spit spit off to er.. They didnt want to do fluids as she wasnt severly dehyddrated=i said but she WONT get up and eat or drink? So they said we can give her the cypro-take her home and see how it goes..i said yes if she DIDNT have massive diareah..she was already tenting of skin on scruff but not on back..they didnt want to do i gently explained my fears of her fading away die from they gave in..gave her 100ml and sent her home..the doctor was pretty mad at me but I told her just do HALF! but it did help..she did eat later that night, did get more diarea and they said no more babyfood..problem is she HATES the texture of canned cat food unless its pudding like. So sunday same thing. lethergic.i had to work and didnt give cypro since at 11pm nite before she had it and i leave at 6am..when got home yesterday she was sleeping in the sun on the window seat..i dont know if she now has a fever, tried the temperature thingy and i couldnt get it to work..kept saying 99.1 and I know thats wrong!! so at 7pm, last night yep another cypro dose, within an hour she ate some food. but still very lethargic but NOT dehydrated YET. this morning I gave another dose,,she is one stuborn cat. spit it out 3 times then wouldnt swallow. I tried the pill popper but I need two hands to open her mouth=she is STRONG!
    so today we are going to my vet and I want to know if we should try a shot of cerenia for nausa, and convenia as she is now snoring pretty bad at night-sneezes sometimes but not offten. has nasal yucks and eye discharge. We are starting lysine them sat night.. and I also want to know why the cypro perks her up a bit, does it have antihistimine properties to help reduce all the nasal issues? and stimulate appetite? She is pooping ok but still soft but no more diarea. And we have been doing the flovent 250 mcg 2 puffs am, 2 at pm. I only had to use the albuteral thur morning because she coughed.
    history: back in january she started snoring pretty bad,..we tried humidifier, etc and nothing helped..we did 7 days of zirthamax and it seemed to help within 3 days! no snoring and now there is..the only thing that does help is putting nose spray in her nose=its only water /salt nothing else-Its a baby nose thingy and the tip is nice and soft and the spray is very gentle but the poor thing she HATES it..I only do her right side nostrol because she totally fights me to do the other side and in the past this side has been totally blocked. I also want to get xrays of her skull to see if something else in there is causing all these problems..last year her asthma was really bad with high pollen, high humidity etc and then furnace running..I DID buy a high hepa air cleaner big one back in decemeber? or jan? and it does help both of us..I have allergies so if I have issues..normally she does too. anyways my case is complicated and long, she seemed to resolve from low platelets but now has a nasty URI that I suspect is herpes virus due to her symptoms and lack of fever SO FAR! Tonight we are going to the vets to get her looked at for either more fluids, or medicine to help..too late for antivirals I know and nothing that I know of will help other than lysine..which is being given just havent seen any results yet. this poor cat has been lethergic thur, sat and yesterday. today she was ok but I am at work..gonna pick her up, and her sister 15 yr old kitty started getting runny eye last night and dialted both are going in tonight. I have 3 cats who do NOT share beds but I HAVE caught the 15 yr old in the 3 yr olds suspect thats how it the 3rd cat lysine all along because she has always had sneezing issues but nothing else-so hopefully I didnt confuse you. the cat that is sick is the youngest with asthma go figure. the other cats are 11 and 15 and all get shots and vet visits twice a year. thank you for any help, yes I printed out your page on URI and will show to vet..who already knows all this anyways but its a shot..thanks for any help, Tonda and sick Honeybee

    • Tonda, you have done an excellent job of presenting Honeybee’s case, and you have written a lot, but I am afraid that it is much too complicated for us to even be able to comment on, especially without the benefit of examining her and looking directly at her laboratory test results. I would, however, be interested in keeping up with her case if you would be able to send us short synopses periodically, we would love to know how she recovers. Best wishes, Dr. Randolph.

  53. I have a 1 1/2 year old, 11 pound, neutered male mini schnauzer who has a UTI. [EDITOR’S NOTE: Click here to read about Urinary Tract Infections.] He was given a shot of Convenia on Thursday March 27th, 2014. I am wondering how long before his symptoms subside? I have to keep him in the kitchen because of the frequent urinating and blood in the urine. He’s not drinking much water, even though I keep it fresh and filled. I changed his food (per my veterinarian’s instructions) to Prescription Diet c/d. Since this is a long acting antibiotic, will it take longer to show some improvements? Thank you for your help.

    • Unfortunately, Tina, there isn’t an easy answer to your question of “How long?”. That depends on the patient’s immune system status, the pathogenicity of the organism(s) causing the infection, whether the infection is complicated by other factors, such as stones in the bladder, urethra and/or kidneys. You wrote on March 27th, so I would expect him to be better by now, though certainly not cured yet. If you are still seeing blood in the urine, ask for a recheck appointment and your pet’s doctor will likely want to radiograph him (X-ray) for urinary tract stones. I am assuming that he saw struvite crystals on the urinalysis and that was his inspiration for using Prescription Diet c/d (an aside: Science Diet is the Hill’s Pet Nutrition’s non-prescription line of foods.)

      As for the length of time before seeing improvement, Convenia achieves a high blood level very rapidly, so, despite it’s long duration, it has a very fast onset of action, too.
      Please give us an update soon so that we may know how your little schnauzer is progressing, Dr. Randolph.

  54. Hi Doctor Randolph and thank you for this wonderful blog. My 8 year old cat, Apricot, was given a shot of Convenia on March 3rd for stomatitis. She hadn’t been eating for at least a month and had gone from 14.5 lbs down to 12. The next two days she started eating again (tuna fish) but then she stopped. She developed diarrhea and I started treating her with Miralax (1/4 teaspoon, twice a day). The diarrhea stopped two days ago but she still hasn’t passed anything. She still won’t eat and I’ve been giving her pedialyte and baby food. She was given fluids on Tuesday. I was able to stay off work this week and take care of her but I need to go back in next week. She is very weak, especially her back legs. She strains at the litter box but produces nothing. I’m convinced her condition is a reaction to the drug and I understand that side effects can happen. Apart from what I’m doing, is there anything else I can do for her?

    Thanks so much for your time

    • Allynn, I can see nothing that implicates Convenia, given that Apricot has a chronic inflammatory disease, stomatitis, has been anorexic for a month and had diarrhea treated with a laxative (Miralax). It is certainly not surprising that Apricot would be weak, given the lack of food intake. This baby clearly needs intensive care, IV fluids, proper treatment for both the stomatitis and the diarrhea. In addition, she probably needs aggressive diagnostics performed to determine the status of kidney function, liver function, electrolyte imbalances and red and white blood cell status and urinalysis. If Apricot’s diagnosis of stomatitis is the kind described in this post, it is a terrible condition in cats that requires aggressive treatment, usually in the hands of a board-certified veterinary dentist. Click here to find out whether there is one close to you, or ask your local veterinarian where he refers such patients when they are in need of more aggressive therapy. If, on the other hand, he is using “stomatitis” in a more general sense, a dentist visit may not be necessary. What is crucial at this point, however, is basic diagnostics and supportive therapy, because it sounds as if Apricot may be slipping away from you. Please keep us posted on her progress with a followup Comment in this section. Best wishes, Dr. Randolph.

      • Thank you for your reply Dr. Randolph,
        Unfortunately, Apricot died at home last week. She had had subcutaneous fluid injections and I was hand feeding her baby food every couple of hours. In the end, it wasn’t enough.

        I don’t know what killed my beautiful girl but I do not think it was stomatitis. She had blood work done and everything came back normal except for a slightly elevated calcium count. She did not have “bad breath” or an elevated white blood cell count. My vet had checked her teeth and mouth and did not see anything out of the ordinary but thought she might have lesions in her throat. That’s why he gave her Convenia.

        I don’t think my vet did anything wrong but I am, obviously, very sad to lose my girl (she was only 8 years old). My vet suggested a rapidly progressing form of cancer but, again, her white blood count (and just about everything else) was fine. I feel like I did all that I could and I am very glad to have been with her when she passed.

        Thanks you again for this wonderful site. I will certainly be consulting here again in the Fall when I welcome another cat into my home

        • Dear Allynn, we are so sorry to hear about your sweet Apricot’s passing. Stomatitis, directly, is not a killer. But, the many secondary conditions associated with it can be. Without access to her X-rays and laboratory test results, I can’t conjecture what did, but there could be many possible causes. You did what you could and you loved her while you had her, and that’s what’s most important. Click here to read an article I wrote about grieving, let yourself grieve for an appropriate time, then, when you are ready, go and volunteer at your local shelter, or perform some other selfless act in Apricot’s memory. That is the best way to honor her. Thank you for your kind words and your readership, Dr. Randolph.

          • I am so sorry for your loss of your little Apricot. You baby’s side effects sound like my little man now. The dr is pretty sure it is intestinal lymphoma. In addition he is running a fever and blood in his urine. He is treating him right now for a possible infection with both Convenia and Orbax. The past month we have done just about everything for his diarrhea, dehydration, loss of eating, weight loss, X-ray showing backup in his little system. My little man is 11 years old. We are making him comfortable and treating him. Hoping for the best. My thoughts and prayers to you and your family.

          • Karen, thank you for writing to comfort Allynn. Current schools of thought imply that intestinal cancer may be much more common in cats with GI problems than previously thought. Thank you for your prayers for Allynn, we have prayed for both of you, and for your kitty to have peace and freedom from pain. Dr. Randolph.

          • Karen,
            Thank you for your kind words. I came back to this site to print out Dr. Randolph’s comments to put them in an envelope with my Vet’s sympathy card and the certificate from “Final Gift” to keep with Apricot’s remains. It was so nice to see that you commented.

            I hope your little fellow is doing better. It is so difficult to see our pets suffer. Do all you can for him but be prepared to let him go if you have to. It is so difficult but, ultimately, the last gift we can give.

  55. Dr. Randolph,

    I, like many other posters on your blog want to thank you for your honesty about Convenia.
    My parents always say the internet will always show you “the good, the bad and the ugly”.
    I don’t even know how I stumbled across your blog but I am happy I did, I will continue to use it as a trusted resource. My little Annabelle had a Convenia and Dexamethasone injection for some skin irritation. It is believed to be caused by a food allergy, so we switched her food to a hypoallergenic variety. I would love to read a blog post about what to look for in cat food, it is increasingly important for all consumers to understand not only what is in all the packaged food they consume, but also their furry loved ones. Annie seems to finally be at peace without aggressively licking, scratching and pulling out her fur. After reading some of the negative things on the Internet I was feeling rather anxious about Convenia, then after reading your blog and feeling more confident in my vet’s decision, I felt compelled to say thank you.

  56. My 6 month old kitten had covenia injection 2 weeks ago and keeps getting swelling in neck leg and now facial swelling how long will this last.

  57. Dr. Randolph,
    I’ve been reading your articles on Convenia and I’m hoping you can help me. My 6 year old cat was given a shot of Convenia Thursday AM to help combat an upper respiratory tract infection. He also has a “bad” tooth that is probably going to be extracted, if we can get him healthy. They also gave him a steroid and an appetite stimulant. Thursday and Friday he seemed to be doing better, but for the past two days he has returned to sleeping all the time and moving like he is 80 years old. He has eaten a bit and seems to be drinking more than usual. I’m worried for several reasons, 1) I expected him to get better, not worse after treatment, 2) I know that not eating is very dangerous for cats and can cause liver failure, and 3) when I visited the Zoetis site, who manufactures Convenia, they list the drug as a treatment for skin infections and abscessed wounds in cats, not respiratory infections. I’m trying to figure out if his current behavior is normal for a “recovering” cat and if I just need to give him more time and I’m also curious as to why my vet would give Convenia when my cat does not have a skin infection or wound. I plan on asking them tomorrow morning when they open but I thought I’d ask you as well and get a second opinion. Thank you.

    • Doctors are free to use medications in any way they can medically justify. When Convenia was approved for use by the Food and Drug Administration (FDA), the provision was limited because for every indication, Pfizer Animal Health (now Zoetis) had to perform clinical trials. To obtain approval for every possible use of an antimicrobial drug would be prohibitively expensive (it’s costly enough for two indications!) and would add no value because the FDA already gives practitioners the freedom to use medications for “off-label” conditions (click here to read about extra-label use of medication). A common problem in cats with Upper Respiratory Tract Infection (URTI) is loss of the sense of smell. If a kitty’s nose is stopped up and he can’t smell his food, he probably isn’t going to eat. IF your kitty’s nose is occluded, use a warm, moist cloth to soften the material in the nose and gently remove it with a Q-tip. DO NOT attempt to go up inside the kitty’s nose any significant distance. You are to limit yourself to the outside and just the first part of the nostril you can see. Cats with URTIs often get worse before they get better and often the primary problem is viral (which isn’t affected by antibiotics) and antibiotics, such as Convenia, are used to help control secondary bacterial invasions. There is no way for me to comment specifically on your kitty because I haven’t examined him, I haven’t seen his chemistry profile and I haven’t seen his Complete Blood Count (CBC). HOWEVER, just because he might get worse before he gets better is no reason not to keep your appointment Monday. As you already know, the liver and many other organs can suffer when an illness drags on unnecessarily. Know, too, that many cats with recurrent URTIs are infected with Feline Leukemia Virus. Click here to read about FeLV. If your pet’s doctor wants to run a test for it and Feline Immunodeficiency Virus, be sure to say YES! Click here to read about FIV. Please keep us posted on his progress.

      • Thank you Dr. Randolph,
        I figured since it is listed as a broad spectrum antibiotic that it could be used in other ways, I just wanted to be sure. We made a trip to the emergency veterinarian last night. I know I seem overbearing and panicky, but I know my cat and he was NOT improving. They gave him a shot of ampicillin and Metacam and sent me home with Clavamox drops. He isn’t happy about the Clavamox, but the Metacam seems to have helped him a great deal and he is currently sitting beside me on the couch instead of sleeping in a corner somewhere (although he is currently sleeping while sitting beside me). We’re going to schedule him for the tooth extraction and cleaning Friday so hopefully that will take care of the issue once and for all!
        Thank you again for your advice! The stuff online about Convenia can be scary, but I’ve had two cats get the shot and (knock on wood) they’ve done fine with it and I don’t have to torture them with pills or liquids.

  58. I just went to the veterinarian because one of my 13.5 year old cats has a skin issue. He is scratching and grooming his face to the point where the skin over his eyes is scabbed. He has even rubbed a part of his front paw raw. The veterinarian thinks it is an allergy and ruled out fleas and ear mites. She gave a Convenia injection for a cat who weighs less than 15# and then she also gave a dexamethasone injection. From my own internet search, I understand the “Dex” is a steroid and Convenia an antibiotic. My main concern is the assistant asked the veterinarian if 12 was too much “Dex” for my cat? The assistant said, “Are you sure that is not too much?” And the veterinarian reassured her 1 per lb. My cat is 12 lbs and the assistant again questioned the veterinarian saying, “But that is 3 cc?” And the veterinarian said go ahead. How is a regular everyday person supposed to understand all this, let alone try to advocate for their pet? Thanks for your help.

    • Your tale is an interesting one, Maria, and I thank you for sending it in. I don’t see that you have too much to worry about, IF the assumptions I’m making are correct. 1, Ear mites are a VERY UNcommon problem in indoor, adult animals. Click here to read more about that. 2, In our hands, Convenia has been a very safe and very effective antibiotic. 3, (this is actually assumption #1), if the dexamethasone you reference is dexamethasone sodium phosphate, it is commonly used for itchiness problems. 4, If the “12” you reference is 12 milligrams (mg.), it is a high antiinflammatory dose. Not unsafe, if used infrequently in a healthy patient, but higher than the “everyday” use of dexamethasone sodium phosphate. 5, The 3cc you reference would correlate to 12 mg. of dexamethasone sodium phosphate in its usual concentration of 4 mg/ml. I have never seen any other concentration of dexamethasone sodium phosphate. 6, The only other issue I see here is that I would not have had the discussion the veterinarian and the assistant had in front of a client, but that doesn’t make her a bad veterinarian or the assistant a bad helper. Just a difference in style, possibly. It didn’t seem to boost your confidence in the team, but, that doesn’t make it a bad team, either. The most important factor going forward is that your kitty gets well and doesn’t have ongoing problems. Or, if he does, developing a plan to manage the problem in a healthy fashion. Thanks for reading, Dr. Randolph.

      • Thank you for your response and concern, Dr. Randolph. It is comforting and assuring to have your genuine expertise in this forward manner. I really appreciate you compiling these responses and have learned much regarding dermatology and convenia. Yes, my cat did get an injection of Convenia as well as 3 cc or 12 mg of Dexamethasone.

  59. Dear Dr. James W. Randolph,
    A little over a month ago my 8 year old domestic short hair cat Cindy started isolating herself from her siblings. She started defecating outside of the litter box. I took her in for an exam (under anesthesia because she is an unruly patient). I was told that they were able to do a thorough exam and that her anal glands were pretty full. They expressed her glands and we went home with the thought that she would be fine. Cindy spent an excessive amount of time grooming her backside and after a week I called the veterinarian because she was still isolating herself and her back side looked very uncomfortable. I was given a cycle of steroids and an antibiotic (clindamax?) to help with the inflammation and possible infection. Another week went by and noticed that Cindy wasn’t eating. I took her back in and she was cooperative under exam without being put under (unusual for her). They expressed her anal glands again and found that they were full. We went home with a steroid/antibiotic cream and a stronger antibiotic Zeniquin. After a week Cindy started to flick her back legs whenever she stood up to walk. She was still not eating and would only get up to drink water. She was also eliminating outside the litter box still. It was suggested that I continue on the steroid, the veterinarian thought that she was in pain and that the steroid would help. Two days ago I took Cindy back in because she was very thin and I thought she was in liver failure. Her bloodwork came back with a slightly elevated white blood cell count and her X-ray looked great. The doctor thinks that Cindy is in pain and therefore won’t eat. She injected her with intense steroids (8 week dose) and antibiotic. She is still not eating and now I don’t think she has used the bathroom in two days. I know you have’t seen her, but can you give me your thoughts?

    • Katrina, I don’t say this very often, but I would seek another opinion. While it might require another sedation/anesthesia, it doesn’t seem that your current doctor is reaching the heart of the problem in this situation. Also, try to take her in with a full bladder so that she can have a good chemical and microscopic urinalysis. Or, leave her with them long enough for her bladder to refill. There are so many differentials that I couldn’t begin to give you a reasonable-sized list. Please DO keep in touch and let us know what the second opinion turns out to be. Best wishes, Dr. Randolph.

  60. My 14 year old cat had a shot of Convenia 3 days ago for an abscessed tooth. He seemed like he was getting better and started to eat but today he is acting differently again and has not had a bowel movement in 4 days. Any advice would be greatly appreciated.

    • Kathy, there are many variables in your kitty’s situation, but one thing is for sure: if he hasn’t had a bowel movement in 4 days because he hasn’t eaten in 4 days, he needs to go back and see his doctor. If he is eating a normal amount and isn’t passing stool, especially if he is obese, he should see his doctor. Cats who don’t eat predispose themselves to liver disease, so that must be addressed. It could be as simple as dehydration, or far more serious.

  61. Hello Doctor, I have a 7 month old Eastern European Shepherd. She started coughing 2 weeks ago. We visited a veterinarian who did a test that diagnosed her with the distemper virus. She was given an unknown shot at that time. Then a week ago I took her to another veterinarian who made an X-Ray, a lab test etc. and he confirmed the distemper. She was given a Convenia shot with B complex vitamin that day. She is still eating good. Mucous and dryness in her nose are noticeable. Her respiration is bad. She hardly wants to go out . I have read that distemper is a fatal disease. What are her chances to live? Do I have to give her another Convenia injection?

    • Sadly, studies have shown that 64% of the medical information on the Internet is either outdated, or just plain wrong. Canine Distemper is usually a survivable condition, with treatment. Some patients can be left with neurologic deficits, but not always. “What are her chances to live?” Without having examined your pet, I cannot say. Statistically, the chances are good, in general, but for your individual pet, you would need to ask the veterinarian who is treating her. “Do I have to give her another Convenia injection?” Fortunately, this is not a decision you will have to make. Your veterinarian will make that decision and advise you. He will also administer the injection, if he deems one is needed. It is not a medication that pet owners administer at home. Please give us an update and let us know how she does, and do not hesitate to contact us if you need more help. Dr. Randolph.

      • Dear Doctor,
        Thanks a lot for your speedy reply. I will consult again the veterinarian once he is back from vacation. At least you gave some hope after reading all the wrong online info about this disease.
        Happy New Year & many happy returns, Adele.

  62. My 8 year old cat, Lou, was seen today by the vet due to constant licking and inability to produce much urine. The doctor concluded that he has a bladder infection and gave him a Convenia injection, the only examination they performed prior to this was by feeling his bladder. He said it appeared to be empty and therefore didn’t collect any urine from him. He put Lou on Hills Prescription Diet s/d, he has been eating and drinking as normal since we returned home. What worries me is that cnce he attempts to use his litter box he becomes angry and irritable, hissing/growling, crying out, roaming around grooming himself. Is this a normal behavior after receiving the injection? Shouldn’t the doctor exam him more thoroughly, like a urinalysis? I called the local hospital and they recommended coming in for a catheter.

    • Leigha, I can’t possibly comment on the examination performed, because I wasn’t there. However, I am a huge fan of second opinions, and you have every right to seek one. Please click here to read a post to better educate yourself about Feline Lower Urinary Tract Disease. It is important to understand that an inflamed bladder is not always an infected bladder. Veterinarians commonly treat this condition symptomatically (click on DICTIONARY, above, and scroll down to the definition of symptomatically) when no urine is present in the bladder to obtain a urinalysis. In some cases, we withhold treatment in hopes of obtaining urine for urinalysis, but the patient’s bladder wall is so inflamed that he empties the bladder before sufficient urine collects in the bladder. If symptomatic therapy helps, but doesn’t resolve the problem, OR, if the problem relapses, we can proceed to more advanced diagnostics to look for complicating factors. No treatment will be instantaneous, but if your kitty isn’t showing improvement soon, he should definitely be seen soon for more aggressive diagnostics and/or treatment. Licking the perineal region has nothing to do with Convenia administration, it, and the signs of irritability you are seeing are a result of the inflammation in the urinary tract. Please let us know how Lou does. Dr. Randolph.

  63. My 3 year old male cat was recently diagnosed with a UT infection. First the vet tried a shot of Convenia; after retesting the urine still showed crystals, bacteria. Another antibiotic was administered (pill) which didn’t work. The vet recommended we do a weekly Convenia shot for 4 weeks. I did not know how dangerous this drug was for my cat until I did some reserch on-line. I have to follow up with another urine test on Saturday. I also did an x-ray to make sure there were no stones or a blockasge (none showing). If the cat’s urine still shows crystalization, should I continue with the Convenia shots or find another treatment. I also have switched him to Royal Canine SO dry food and Blue walnut cat litter. This UT infection has run almost $800 so far and I’m still dealing with it?

    • Lynn, the first thing to understand is that bacteria represent infection, but crystals represent a mineral problem that may result from improper dietary mineral content or improper pH of the urine. Crystals may also represent stones in the bladder (more common), the kidney(s) (less common) or both. First, click here to read about FLUTD, the syndrome of urinary tract inflammation in cats. Second, click here to read about bacterial culture and sensitivity. This is the test that tells your pet’s doctor whether the antibiotic he is using will be effective on the bacteria participating in your cat’s infection component. BOTH problems must be addressed. Click here to read about the diets we use for problems of this type, HOWEVER, DO NOT SWITCH FOODS WITHOUT YOUR LOCAL VETERINARIAN’S APPROVAL! Failure to use the correct diet can result in treatment failure. FLUTD is a complex condition, but one that is almost always manageable. Let us know if we may help further, Dr. Randolph.

      • Dr. Randolph, thank you for explaining to me all the different possibilities when dealing with a UTI. It helped clarify this complex condition. Bow Tie passed his last urine analysis and seems to be doing well on the special SO diet. The Royal Canin SO diet is a little expensive being I have 4 other cats that are also eating the dry food; but if it keeps the UTI infections to a minimum it is well worth the cost. I appreciate your quick response and helping me understand further this complex condition. Lynn

  64. “I found your Web site one night, hysterical after my cat Booba had been given Convenia, for UTI. You lovingly told me to calm down and that he would be fine, and guess what? He was!!! So much bad stuff online about that particular med, but it was a good drug for us, and fixed his UTI. Thanks for helping me to feel better that evening. Your reply was quick and really helped me chill. Much love!!! Thanks so much”

  65. My beloved booba got this shot today for urinary infection, and I come home and Google it, and now I’m so scared this shot may kill him. The Google return search for this medicine is scary, and if I had known better I’d chosen a more traditional kind of treatment. If your fur baby does have a bad reaction there is very little they can do, because this medicine is long acting. I’m trying to be fair here in my judgement, and anxiety over the administration of this shot. I chose this site to go to, to leave a message because at least some good things are said about this medicine. How often does this medicine kill fur babies? please help. Thank you

    • Take a deep breath. Whenever you go online to look up medical information, keep in mind that 64% of the medical information on the Internet is either outdated or just plain wrong. And, that’s not counting the “stuff” that is written by the opinionated, uninformed element. By contrast, when something we’ve published on becomes outdated, we take it down! There is a lot of hoopla about Convenia, but how much has been substantiated by laboratory testing and necropsy? Very little. In the years I’ve administered Convenia for both on-label and off-label uses, I have had ONE (1) bad outcome, which was clearly an allergic reaction, was treated and the patient did great. I have spoken to Pfizer Animal Health (now Zoetis) extensively about the safety parameters of Convenia. They are legally bound by the Federal Food and Drug Administration (FDA) to disclose problems with medications. Usage history simply does not match the vitriol on the Internet. There is no reason to suspect your Booba will have any problems from Convenia, much less die! If you would like to read more of what we have posted about Convenia, simply type Convenia into the SEARCH window in the upper right hand corner of this or any page on and press the Enter key. I have written about it extensively because it is a wonderful tool in the veterinarian’s toolbox that does wonders for the vast majority of patients for whom it is used.

  66. […] wasn’t happy about it, but the antibiotic shot he received means I don’t have to pill him twice a day for the next 10 days. That’s a […]

  67. I took my 13 year old cat to the veterinarian today and he gave him a shot of Convenia. He has had diarrhea for about a month and he is impossible to medicate, pick up, etc. It was a miracle I even got him in the carrier to go to the veterinarian. Anyhow, is Convenia used to treat diarrhea? He had a temperature of 103 degrees and without doing a lot of tests, the veterinarian wanted to try the Convenia as he thought it was probably an infection. I am a bit confused, however, as I read that a side effect of Convenia is diarrhea.

    • Thank you for your question, Judy. Sometimes difficult-to-handle patients put veterinarians in the position of doing the best they can, even if it is not ideal. That may be the situation here. I cannot say for sure because I’m not there and I’m not examining your kitty. That said, bacterial overgrowth of the intestinal tract is not only a real syndrome, it is fairly common. Please click here to read about how those “side effects” of medications are determined. Other methods of treating your kitty’s diarrhea might involve oral and/or intravenous medications. Will he be home tonight to get his oral medicine? Will he sit still and allow you to administer oral medication? Those are some of the challenges we face in dealing with difficult-to-handle patients.

  68. My 1 year old dog was attacked by another dog on Saturday and lost an eye. He is in post-op recovery and was doing ok until he began shaking and shivering. I rushed him to our usual veterinarian to have his temperature taken. He had a fever and temperature of 104. The doctor, through a series of questions, realized the operating veterinarian at the emergency hospital did not give him an antibiotic, post surgery (only tramadol and carprofen). So our Doc gave him an injection of Convenia and an injection of a corticosteroid (dexamethasone). He said this would help with the fever and aid in the reduction of swelling of incision (which is already almost healed and ready for suture removal). We brought our pup home and he rested and stopped shaking. However, two days later, he’s begun shivering again. Is this a sign the fever has returned? We have an appointment scheduled for Monday (two days away) for stitches removal and can see our doc then. Should we keep him comfortable until then or rush to a hospital?

    • It is an easy process to take your pet’s temperature. Go to any drug or retail store and purchase an electronic thermometer and some thermometer probe covers. Put a little lubricant on the probe cover (K-Y jelly, Vaseline or cooking oil), lift your pet’s tail and gently insert the tip of the probe. 1/4″ to 3/8″ is plenty. If you have an assistant, have the helper hold your dog’s head and gently caress and speak to him. The electronic thermometer will beep when it is finished, and you can take the reading. Normal body temperature for dogs and cats is 101.0 degrees Fahrenheit to 102.5. Most dogs run toward the lower end of that scale. If his temperature is elevated, you should plan to see your local emergency clinic. If not, AND if he is eating, drinking and otherwise acting normal, you can wait until Monday. Please let us know how he does.

  69. About 6 years ago, my then 11 year old kitty was diagnosed via scope (a few polyps removed also) with a Pasteurella bacterial nasal infection which was treated using azithromycin. Several months ago, she started shaking her ears and I took her to be checked and they appeared to clear. However, she started again with the mild fluidy purrs she’d exhibited 6 years ago with the sinus infection. A urinalysis showed blood and white cells. She had a shot of Convenia 13 days ago. Around day 10, the fluidy purr seemed a bit better, but, after my being gone for a few days, on arrival home, I found her purring to be very fluidy again. Should a second shot be given, since the first one did not take care of the problem, and should a second urinalysis be done before having another shot? She has renal disease and has just been diagnosed with hyperthyroidism.

    • The decision to repeat the Convenia injection is completely the purview of your veterinarian. However, I have given multiple Convenia injections to many of our patients with complete safety. If you would like to read more about renal disease, click here. If you would like to read more about hyperthyroidism, click here. To read even more about hyperthyroidism in cats, use the search term MMHT4 in the search window in the upper right hand corner of any page on

  70. I have a 15-16 year old cat I adopted last year who seems to have chronic Upper Respiratory Tract Infections. He gets a Convenia injection, and does quite a bit better for 1-2 months, then gets symptoms all over again. Is it OK that he’s getting a Convenia injection repeatedly? I’ve read that even though it’s only active for about 14 days, it’s in the body for 2 months, so now worried that his just getting another injection after just having one just over a month ago isn’t good, though the veterinarian didn’t indicate it should be a problem. As for his chronic URIs, is there anything else I can do to try and get rid of it permanently, or might it just be something we have to deal with in an older cat with possibly weakening immune system? Thank you.

    • Thank you for your question, Xan. Cats infected with Rhinotracheitis, a Herpes virus, will have relapses regularly. Click here to read a comprehensive outline of upper respiratory tract diseases. IF Herpes virus is his problem nothing is going to completely clear the viral component of infection because Herpes “hides” from the immune system in nerve cells and comes out when the immune system is under stress. Age is a common cause of immune system dysfunction in all mammals. Antibiotics cannot help with viral infections, but are crucially important in controlling secondary bacteria. I, too, have found Convenia to be effective in many of these cases, and have more than one patient on long-term, repeated use of Convenia with complete safety. Also, ask your veterinarian about using immune system supports such as Enisyl. Tagamet has been shown to help some of these patients, but you will need to get the proper dose from your pet’s doctor. We wish you well and stay in touch, letting us know periodically how he is doing.

      • I had my 4 month old kitten at the veterinarian today with 106.7 fever. Bloodwork showed some anemia and low WBC, 3.3. She suffers from FHV more in the eyes(conjunctivitis). Today they gave her a shot of Convenia and she’s so lethargic, and won’t eat. Was it smart to give her a shot because her WBC was so low?

        • 106.7 is a VERY high fever, even for a kitty. (Cats tend to be able to run higher fevers, on average, than dogs.) She was sick before the Convenia injection, so there is no reason to think the lethargy and anorexia are Convenia-related. When we see fevers, we know there is a source of inflammation, and there is a good chance that inflammatory process is related to infection. If the infection is coming completely from Feline HerpesVirus (FHV), the antibiotic injection won’t help, except to give her protection against future bacterial invaders. That said, a patient with a 106.7 temperature probably has bacteria on top of her FHV already. The WBC may be low because the immune system is in danger of being overwhelmed, in which case she needs all the help she can get to keep the disease process from worsening. Given the information I have here, I’d say your pet’s doctor did exactly the right thing.

          • Thanks so much! Today she is great! Eating, playing and grooming. I think the Convenia helped her! So I shouldn’t scare myself by reading all the negative effects of this med. Glad to be waking up to a lively kitty. Yes, that temperature scared me luckily it went down to normal in 3 hours following an antiinflammatory shot. If she’s an indoor cat how can she get a bacterial infection? Veterinarian didn’t suspect it and said it’s all viral and most likely from the Herpes virus. Hopefully this Lysenix will suppress the virus and this never happen again. I was so scared for Snorkels.

          • Bacteria are everywhere. They’re all over you, they’re all over me, and they’re all over everything in our environments. A good place to grow, like a sick kitty, isn’t hard for a bacterium to find, and it isn’t hard to find the bacteria to fill the bill. Unfortunately, a lot of unqualified people have said some really bad things about an extremely useful tool, Convenia. We are delighted to know that Snorkels is so much better!

  71. I need advice on the Convenia injection for my cat. She went to the veterinarian last year November, 2011. She was drooling and had loss of appetite. Veterinarian said she had a bad tooth but couldn’t diagnose completly due to my cat not cooperating (go figure). Anyway I asked about an antibiotic injection to try first. So my cat was given Convenia and within a day her drooling stopped and she was back to her normal self with no side effects whatsoever. Worked great! Now almost a year later she is not eating again which is VERY unlike her. No drooling this time just the eating issue. She is not acting sick per se but definitely an issue there. I am wondering if it is the tooth or not. So long story short she is going back to the veterinarian and now after reading all the horror stories of the Convenia shot I am very leery to try it again. Please help with any advice! Thank you.

    • Crystal, let’s begin by addressing some basic issues. 1, Your kitty needs a thorough examination to first determine the cause of the problem. If the doctor thinks it’s a tooth issue it’s worth a sedation for a thorough examination to know for sure if there is a tooth problem. When tooth roots become infected antibiotic therapy alone rarely solves the problem. Usually the tooth must be extracted to allow irrigation and drainage of a plugged-up abscess. 2, Just because she had a tooth problem last time (or didn’t, since there was no definitive diagnosis) she quit eating doesn’t mean it’s a tooth problem again, thus, see #1, an examination is imperative. 3, you can read horror stories about anything and everything on the Internet. Just because someone SAID Convenia injured their pet doesn’t mean it’s so. In every case I set out guidelines for what should be done in case of an adverse event. You may click here to read that post. How many of the claims of Convenia injury are backed by exhaustive investigation? None that I have seen. 4, My professional experience with Convenia has been flawless with the exception of a single allergic reaction, which was easily treated with medication and resulted in no other medical problems. I have used “gallons” of it and stand by its safety profile.

  72. My cat was given this shot for an ulcerated cornea that may be related to having Chlamydia in her eye as a youngster. I am concerned that this is a case of over-treatment; a 2-week antibiotic for an eye infection that was improving? I might have refused but wasn’t told it would last 2 weeks until the injection was underway. A main concern is whether this will destroy intestinal flora like oral antibiotics do?

    • Byron, it’s not unusual for cats with ocular Chlamydia complaints to also have upper respiratory complaints, so I’m guessing (and it is only an informed guess, having neither examined the patient or spoken to your veterinarian) that he was concerned about secondary bacterial infection and chose Convenia for that. While I always give clients a choice between oral medication and Convenia when it is indicated, (especially in cats and frequently in small dogs) almost no one chooses oral medication over Convenia anymore.

  73. Our cat suffered with an intestinal infection for 6 months. I took him to a new veterinarian and the doctor gave him a series of two shots of Convenia two weeks apart, and it was like a miracle. The former veterinarian changed his diet, treated him with other antibotics and nothing worked until he received Convenia. We will be forever grateful for this wonderful drug.

  74. My cat Chobe has had chronic pancreatitis for almost 2 years. He is maintained on an oral antibiotic but recently had an acute episode when it got a lot worse. Chobe has now had 2 Convenia injections (I’m getting ready to give him his third injection) and he is MUCH better. His insulin needs have gone back down and he is much more active – almost symptom free. I understand that antibiotics don’t necessarily work for an acute episode of chronic pancreatitis – but it has sure helped my kitty and I thank you.

  75. Hi Doc, my cat was given Convenia for her UTI which was very bad (blood and all) on Friday night and today is Tuesday. I thought she was doing well, until this morning when I saw blood on my floor again. I was so heartbroken all over again. I thought was recovering and now blood again. She is also on methigel, and special food to help her with her UTI. What do you think this could be?

  76. Im a 10 month greatdane female i need convenia again…my mother put like 3000$ on me since 6 month i had demodex ive been sterilised for less come back of this and after all that i loose my fur my skin is dry i try the natural method since one week…can i die fault of no convenia my weight 120 pound im lazy , anxiety , shake … =( how much for convenia please help be i buy right now i love my mother and she love me im her queen wait for answer thks xx

  77. Nine year old male cat with Crylotkorax. Doctor drained the chest area of cat drawing about eight ounces of fluid. Doctor then give cat Convenia and Vetalog when stable. On hour later cat had rapid breathing and heart rate. Dealth resulted. Any feed back?

  78. My 10 week old kitten was given Convenia for a upper respiratory infection. How long does it take to see improvement? He is sneezing and coughing.

    • Debbie, there are so many factors in upper respiratory tract infections of cats there is no way to give a one-size-fits-all answer. Fever, congestion, amount and location of congestion, whether cough is present in addition to sneezing, other complicating factors, such as diarrhea, percentage of illness caused by viral disease versus bacterial disease (I could go on and on). I would say if my kitty were not eating in 3 days or if he were not substantially improved in his respiratory tract signs in a week I’d be on the phone, making another appointment with my veterinarian. Best wishes, Dr. Randolph.

  79. My cat Max 19 months old had a large open wound on Friday his skin was torn up and you could could see the muscle on his gluteous. We don’t know how this happen since he is an outdoor cat during the day. We took him to the vet on Saturday and they flush and closed the wound. He also got an injection of Convenia. First when he was examined on Saturday he had a temperature of 103. Is Monday now and his temperature is over 104. I when back to the vet and got another antibiotic injection Baytril and IV fluids. I don’t understand why the first antibiotic Convenia didn’t work since is a long lasting antibiotic? I’m concern about his still fever and how long is going to take to be resolved? Thanks!

  80. Update 2: The barium moved through to her colon over 6 hours. They described this as “slow, but no clear indication of an obstruction.” I brought her home and she is resting. I removed the fentanyl patch and that seems to have helped slightly although she is clearly in discomfort still as evidenced by her whining. Basically, 3 days, $2,000 and many injections and stressful trauma to her later? They still don’t know anything definitive as to a cause. I’m beside myself and inclined to keep her home for awhile longer to see if she improves/develops any appetite. VERY heartbreaking/frustrating.

  81. Dog is in emergency care facility for past 9 hours undergoing barium xrays to check for blockages. So far, no blockage detected and barium is 1/2 thru intestines. Will call in 3 hours for status report and I’m told if no blockage is detected, they will keep her overnight and try to feed her. Until they detect blockage (likely necessitating surgery?) or she eats on her own if no blockage is found, they will keep her there on IV fluids.
    P.S. so far the bill is $2,200 and they still don’t know what’s wrong and she still wont eat or drink on her own.

  82. Help please! My 1 year old German Shepherd stopped eating 3 days ago. 2 days ago she had terrible diarrhea (no blood but mucous), and vomiting all day until she vomited yellow bile. I took her to my veterinarian. He felt her abdomen and she yelped. He did blood work and a stool test and gave her subcutaneous IV fluids along with B-vitamin injection and an anti vomiting injection. He sent us home with carafate and Cerenia. He called next morning with blood/stool results and said he found no organ damage and no worms so he said he “assumes it’s a gut bacterial infection”. My dog refused food, refused carafate and cerenia so I returned to the veterinarian. They took an x-ray and determined there was a lot of gas in her belly and her spleen was quite enlarged. They gave her an injection of Convenia and a fentanyl patch on her skin. I took her home.
    She still wont eat or drink. It has been about 10 hours since the Convenia injection. She’s lethargic, her stomach is rumbling, she wont eat or drink and I’m worried I’m not doing enough. Should I get an ultrasound on her spleen? I believe enlarged spleen can be symptomatic of bacterial infection or alot of other maladies.
    What should I do? How long can a dog survive without food? Should I force-feed her Pedialyte or water or take her to an emergency care for IV fluids tomorrow if she still hasn’t drunk anything? How long should it take for the Convenia to work and if it works will she regain her appetite quickly? Thanks!

    • Robert, there are simply too many unknowns for me to give you meaningful advice. My fear is that your dog may not have time for more trial, and may need the special services of a board certified internist to sort out her specific problems and get her on the road to recovery before she goes so far down that she can’t recover. Ask your local veterinarian for a referral Monday morning, and please let us know what you find out. Best wishes, Dr. Randolph.

  83. My cat has leukemia. Always gets ut infections. This time they gave Convenia. After 14 days cat has no white blood cells and is anemic. He is dying. They never ran tests before giving him this drug to see how bad his aniema already was.

  84. My 3 month old puppy has kennel cough. The veterinarian gave him Convenia shot for it. It has been 3 days, and he is not getting better. Was Convenia the right choice? I don’t see it mentioned as a treatment for kennel cough on any of the pet forums.

    • Inna, first realize that there is no such thing as “kennel cough.” Click here to read more. Assuming your puppy has an uncomplicated upper respiratory tract infection, no pneumonia, it can sometimes take longer than three days for improvement. Also, especially this time of year, he must be kept in a protected environment, out of the cold, rainy weather. Indoors, in other words. Most cases require a cough suppressant to break the coughing cycle. If he’s not also on one of those, ask your veterinarian. Please don’t read “pet forums” for medical advice for your pets. Ask your veterinarian. Or a veterinarian you trust. If you continue to read and trust us, we believe you will find us reliable.

  85. My 7 year old male cat was into the veterinarian Nov. 10 because there was blood in his urine. I took a urine sample in and we discovered that he was full of crystals. I was told to administer a pain medication for 3 days – torbugesic – change his diet to Hill’s Prescription Diet c/d and to try and get him to drink more fluids. After a few days he seemed fine but 3 weeks later he was once again having blood in his urine. I took another urine sample in and this time there were no crystals but a bacterial infection. He was given an injection of Convenia and appears to be fine however he still has “some” blood in his urine 6 days after the injection. Is this normal and how long should it take for the blood to clear out?

  86. We moved from Long Beach and miss Dr. R. VERY much !!

    Certainly the BEST VET we’ve ever had !!

    Thanks !

    — B and C

  87. Hi Dr Randolph, I have 2 exotic short haired cats (sisters from same litter). One of them has been acting really strange lately, excessive grooming and also licking walls. She is eating ok, but has lost weight over last few weeks. I took her to the veterinarian this morning, she said that her glands were up on her neck, and took some blood for testing. They did FIV and Leukemia while I was there both were negative. They have sent the other blood off for testing. Asha was given Convenia and Dexafort injection. I was just wondering if there are any side effects I should look for and is she ok to still be around her sister? Thank you.

  88. Dr. Randolph, My husband took our cat to the emergency veterinarian since it was after hours. Zidi (our cat) was very dehydrated. He was given fluids. Other tests were done and nothing was found. His temp and vitals were normal. He did come home and was acting “normal.” However, he would NOT eat his dry food. He kept crying for us to give him his “sisters” dry food. I called our regular vet in the morning to brief him on what happened. He was surprised with the reaction as well. We have Zidi on a different dry food that he seems to enjoy. My main concern now is his behavior…he is just not acting like the cat I knew from 10 days ago. I can only say that he is acting differently. Any thoughts?

  89. I help care for a large, stable feral cat colony who live around a school here in Albuquerque. Two weeks ago, we re-trapped an already ear-tipped (i.e., already neutered) feral with a terrible upper respiratory infection. He had green gunk coming out of both nostrils, a gunked eye with some clouding of the cornea, and stringy drool hanging from his mouth. I took him to our local humane association clinic for a Convenia injection and concurrently gave him Clavamox for about a week (administered in his food, wasted several doses until he started eating), then Amoxicillin for the second week. He is much better, amazingly so–no more drooling, eye not gunked shut but still a bit cloudy, eating well. However, I can still hear his breathing and when I shine a light I can see some fluid still in his nostrils. Is it advisable to see if the humane clinic will give him another Convenia shot before I release him? Or should I be asking about some other antibiotic because he’s already gotten the benefit of the Convenia? I am very worried about releasing him back to the colony while he still has fluid in his nose/throat, especially because winter is here and it’s bitterly cold at night. However, it’s not humane to keep him confined indefinitely either–maybe for another week or so to help him gain more weight? The colony is regularly fed dry food, but if he gets sick again and can’t smell it he will probably stop eating again. I also wonder whether I need to gradually re-acclimate him to the cold before releasing him after he’s spent two weeks in a warm garage. Thank you so much!

    • Tania, my first concern is about this kitty’s immune system status. Chronic respiratory infection, especially when accompanied by keratitis which may be herpetic and recurrent are strong indicators for immune system suppression. Are funds available for FeLV and FIV testing? Is there money for testing the cloudy cornea for herpesvirus? Is there money for antiviral medications if the test comes back positive? I don’t imagine you’re going to hurt the kitty with another Convenia injection. Lord knows he faces meaner things than that on the street every day! It is possible to do more harm than good when combining antibiotics, and there are more effective combinations than either of the ones you chose. Ask the doctors at the shelter about some other possibilities. Let me know if I may help further, and God bless you for the work you do for these who can’t speak for themselves, Dr. Randolph.

  90. My 17-pound cat went to the veterinarian this morning and was diagnosed with a bacterial infection. (The skin was all pink and irritated on his tummy and underside of his tail). He received Depo Medrol and Convenia. My cat is now lethargic, eyes are a bit glazed, doesn’t purr when I pet him and won’t take a kitty treat. Could he be having a negative reaction to the Convenia? Is this a “normal” reaction to Convenia? Or a combination of the 2 drugs? I am worried. He is just not himself. If he is having a negative reaction, what can the veterinarian do to make him feel better? THANK YOU!

    • Alana, this is not typical for reactions to Convenia. It’s more likely that the infection is causing him to feel bad. Did you call your veterinarian? What did he say? Some cats and some dogs will feel and act lethargic after Depo Medrol injections. Stay in touch with your pet’s doctor. He knows best what his patient needs, as he’s there and actually seeing your kitty and measuring his vital signs. Don’t be hesitant to let the veterinarian perform laboratory testing if he asks. Let us know if you have more questions, Dr. Randolph.

  91. My 8 year old cat was given Convenia to treat a pretty bad bite in the face and subsequent cellulitis (likely a bite from another cat) about two weeks ago. I was so grateful for the long acting injection. Giving this cat a pill, given the bite location on his face, would have been painful, and a challenge. I’m happy to report no side effects, and a full recovery. I have 4 cats, and I will always ask, going forward, if this antibiotic is an option. I am “ok” at pilling my cats, but it is often a little violent, and sometimes, I wonder if I really got it in there:) Then there is trying to get them out from under the bed at pill time. When is Convenia a good choice? When are other antibiotics preferred?

    • Thank you for a great testimonial, Susan. Convenia is a good choice whenever cost is not a factor (in most cats and small dogs oral medications are going to cost as much as Convenia anyway), when the infection being treated is susceptible to the active ingredient in Convenia and, especially, when the patient is difficult to give oral medication to. We hope he heals fully and without complications.

  92. My cat is 16 years old and got a shot of Convenia for anal sac infection. She would not eat for 3 days and had diarrhea. She had to be sedated which is also very hard on her. The veterinarian insists she needs another shot in 2 weeks. Is this true, since it’s so hard on her?

    • Freia, in my experience most anal sac abscesses will heal adequately and resolve infection with 14 days of antibiotic therapy, which Convenia provides (in ideal cases…the range is 10-14 days). The factors to consider are: 1, do we know that her loss of appetite was from Convenia and not from the abscess? 2, Were there possibly other causes for the diarrhea? 3, At the time for the next Convenia injection ask your veterinarian to examine your kitty well first, deciding whether another injection is necessary. Best wishes, Dr. Randolph.

  93. My cat Molly had injured one of her rear claws. I took her to the veterinarian and they decided it was best to just leave it alone and let it heal since the upper part of the nail was still there. They gave her a shot of Convenia as a precaution against infection. The nail is healing up just fine but now she has diarrhea. I know this is a potential side effect but she didn’t get full blown diarrhea until a week after her shot. At first it was just slightly mushy poop which has slowly progressed to diarrhea. Everything else is fine. She eats, she drinks, she plays and is otherwise her normal mischevious self. Do you think it could be from the Convenia? I am currently giving her metronidazole with the hopes of it helping to clear things up. I have an IBD kitty and know that the protocol at my veterinarian’s office for a kitty with diarrhea is this particular drug. I just didn’t want to rush her off to the veterinarian to only be given medicine that I already have plus if this is just a side effect of the drug and will clear up on its own then I don’t see a need for a veterinarian visit either. This Tuesday will be 14 days since she has had the shot. If it is a side effect how long will it go on for? If it doesn’t clear up by Thursday I will definitly be calling my veterinarian.

    • Rachael, why not just go ahead and call your veterinarian now, and let him know your kitty is having difficulties? He’s treating your other kitty for IBD, so he knows what medications you have on hand, he will either say that he wants you to use that or he wants to dispense something different or he feels your kitty needs to be seen. Best wishes, Dr. Randolph.

  94. We had our cats laser declawed 2 weeks ago. We noticed that they felt like they had fevers 6 days later, so I took them back to the veterinarian for fear of infection. Everything looked great, but after doing blood work the found that had a virus of some kind. The veterinarian gave them both Convenia to prevent any infections in the paws, mainly because their immune systems are weak from the virus. But now I’m noticing our 7 month old boy seems to be having labored breathing. He had the shot a week ago. Should I be worried yet? I’m not sure if its a side effect from the medicine or not. He isn’t wheezing nor does he seem to be in discomfort of any kind.

    • Yes, Kelly, you should be worried. It is unlikely that a reaction to Convenia would take the form of labored breathing, but the “virus” (did the doctor say what kind of virus?) could be causing anemia or other problems that are resulting in the breathing difficulty. Please let us know what the doctor says. Best wishes, Dr. Randolph.

  95. My cat had a superficial seroma drained and it was sent to the lab…no infection.
    She had a temp of 103. The veterinarian said she “looks great, healthy” when we left after the drainage and 24 hrs later I was phoning their office in a panic. She was given Convenia without my knowledge, I was told after my veterinarian returned with her following the drainage. Within 24 hours my cat was a completely different animal when I returned from work. She looked like I pulled her from a drainage ditch. She had a screeching meow. I went online to see read about antibiotic reactions in cats and learned about Convenia. Since my veterinarian was out for two days and I was told to wait by another veterinarian at the office, until the next morning to bring her in…that it would likely be fine to wait. To make a longer story short, my cat had to be hospitalized for almost three days and received a different antibiotics and steroids. She has not recovered…she is home now and is taking steroids and oral antibiotics. She is completely lethargic and I am praying she recovers. It has been one week and she is still sleeping all the time and cannot do anything except lie down. I am certain she had a bad reaction from this “convenient” drug. I really would have like to have known the risks. It is not worth the convenience to go through this kind of anguish now. If this happened to a human…there would be consequences that would make the practitioner more careful.

  96. Hi Dr. Randolph, I adopted a 5 year old poodle mix (small) from the shelter here about 6 months ago. Today I just took her to the veterinarian because I noticed her urine had a little bit of white in a small part of it. Turns out she had a very high bacteria level in her urine and a small amount of pus. After running tests and confirming it was vaginitis the veterinarian gave her a shot of Convenia, 80mg/ml, she weighs about 11.4 pounds. This is her 2nd UTI since we’ve come home from the shelter. For the first one they gave me a packets of pills and had me give her one a day. Do you think the Convenia will work for this bacterial infection in her urine as good as the pills? They didn’t give me any details of her urnalysis, just that there was a little white “pus” in her urine which (and I quote) “looked like the bacteria was having a party around”. For the Convenia injection I paid $49, which is fine I’ll pay to my doggy better, but the pills I got previously were much cheaper (I think around $18). I just want to make sure this works and it is the right thing my veterinarian did. I have to take her back in 14 days for another urinalysis test, which will cost approx $100 for the urinalysis test, urine sediment exam, urine specific gravity and medical waste disposal fee (these are all the things they charge for in these urine tests). Does this sound right? Thanks for any help. I just want my dog to not get these any longer, I feel bad for her. Is there any other steps I can take in help with prevention of UTIs? I take her on walks every 5 hours, she always has fresh water. Should I start giving her spring water? I read that is good..but didn’t know if that is accurate information. Thanks for your help.

    • Kristina, this is a hard question to answer. First, vaginitis and UTI are not the same thing. Vaginitis is inflammation of the wall of the vaginal vault. Inflammation may be caused by infection, as well as a number of other factors. Urinary Tract Infection (UTI) describes infection that is affecting the urethra, urinary bladder, ureters and/or kidneys. Laboratory confirmation of bacteria seen on the microscope tells us there are bacteria present, but it doesn’t tell us which part of the urinary tract they came from, OR which antibiotics will work best. For the latter a Bacterial Culture and Sensitivity is required. I usually give clients a choice between Convenia and oral medication and the choice is usually determined by the pet owner’s ability to pay and the known difficulty level of giving pills to the pet. Perhaps you should speak to the doctor in advance if you prefer to have pills. Will the medicine clear up the problem? Without a culture and the known/unknown of complicating factors for UTIs, we just don’t know, but UTIs that don’t respond and stay gone deserve a more in-depth workup as you will read in this post. Best wishes on your dog and please let us know how she does, Dr. Randolph.

  97. Dr. Randolph, my cat, Fang is a rescue from a shelter. He has what I believe is a respiratory infection caused by Pasteurella. He has had blood work, cultures, x-rays and laparoscopy to remove a mass in his sinus cavity. The cultures pointed to Pasteurella. My veterinarian administered the Convenia injection and gave us oral antibiotics, Clavamox. We went through several cycles of the Clavamox to no avail. The Convenia seems to do the trick. Next he gave us Orbax (Orbifalxicin). He has been through two bottles and no improvement. We have been doing this regimen for 9 months now. Finally our veterinarian prescribed the Convenia again, but we are administering it ourselves (veterinarian is an hour away). As I mentioned he always is better after the injection, but as it wears off he goes right back to being in poor shape. Is there any harm in using Convenia forever? Should I expect this forever? Fang is approximately 3 years old and he is a Bengal, possibly a mix, but I think full-blooded. He eats well and is very active. He weighs 10.4 lbs. He just can’t breathe a lot of the time and it breaks my heart. We have another rescue, a Bengal, and he shows no signs of infection. We got him after Fang and seems to have lifted Fang’s spirits. If you have any suggestions I would be forever grateful! Thank you for your time.

    • I don’t think anyone knows what the long-term effects of using Convenia will be. The FDA has approved Convenia for two consecutive injections, but has put no limitations on a time period between series of injections. In other words, if Fang got one injection today and needed another in six months, that would be acceptable to the FDA. That said, as doctors we often operate outside the parameters of label limitations with off-label techniques, described here. So, with owner approval your pet’s doctor could administer a series of Convenia injections beyond the approved two and continue those as long as they are helping. You, of course, in giving your approval, would have to accept the risks. Would I feel safe in taking that step for my own pet? Most likely, given the right circumstances. One factor to consider is that with many of our chronic dermatology cases we use cephalosporin therapy for as long as six months with excellent safety. It is not a huge stretch to assume that Convenia would have that same level of safety. Chances are good that Fang has some other secondary factor going on, such as Feline Viral Rhinotracheitis, Feline Leukemia Virus and/or Feline Immunodeficiency Virus immune system suppression. Enisyl and certain other immune system stimulants may help. Be sure your pet has two FelV/FIV tests separated by two months which agree with each other (both negative or both positive for either or both viruses).

  98. My mature male cat has had 3 injections of this medication. The most recent was the 12th of October. He now has developed, since the last injection, diarrhea, lethargy, decresed appetite, decreased water intake and limping gait. We have had him to the veterinarian and blood work and stool Gram stain showed a left shift in his CBC . We are supporting him at home with subcutaneous fluids, Fortiflora in his food and Pepcid daily. We have had to syringe-feed him to get calories in him, otherwise he prefers to sleep. This is a significant change from the cat three weeks ago when he had his 2nd injection. We are treating a staph sinusitis from a foreign body in his sinuses. What is the half lfe of the medication? I am truly fearful for him.

    • Sharon, I’m not sure about the half-life but the duration of the injection in most patients is has a 10-14 day duration. Typically injections are given 14 days apart. The signs you say your kitty is demonstrating are among the reported signs that occur in some pets, though I have not seen them in our practice. Staphyloccoccal sinusitis can easily interfere with appetite, too. Most cats unable to smell will not eat. Ask your veterinarian about vapor treatments that might open his airways. Also, ask him how he feels about using metronidazole as an intestinal antiinflammatory. I have had success with it in cases such as this. Fortiflora will be very important, too. Especially with oral cephalosporins we use beneficial bacteria when reactions occur. Please keep us posted so that we may know the outcome of your kitty’s situation. Best wishes, Dr. Randolph.

  99. My 14 year old big boy (20 lbs) Foozi was diagnosed with diabetes and a UTI on Friday. Convenia was given to fight the UTI and I was given insulin to administer twice daily with food. Unfortunately, kitty has completely lost his appetite. Could this be a result of the Convenia? If so, how long will the side effect last? Everything I’ve read is pretty clear that insulin should not be adminsistered on an empty stomach.

    • Dear Foozi’s Mom: Feline diabetes is a MUCH too complicated topic to cover in a question, but it’s far more likely that Foozi isn’t eating because of his diabetes than from the Convenia. Remember that 64% of the medical information on the Internet is either wrong or outdated! ( ). So, be careful there and get your advice from a trusted source, such as us, or your pet’s doctor. ( ) Depending on what Foozi’s blood glucose and fructosamine levels are he PROBABLY needs insulin whether he eats or not. I put “probably” in all caps, bold and italics because I don’t know what his glucose and fructosamine levels are AND I don’t know what the rest of his labwork results are. In my hands Convenia has been a fabulously safe antibiotic and extremely effective. UTIs are very common in diabetics, so be sure to have the proper followup performed to ensure the infection is all gone. Write back if you have more questions, Dr. Randolph

  100. Can Convenia be used to help respiratory problems like sinusitis? I have a cat who inhaled (possibly) ant spray and ate the ants and was having rapid breathing. He seems like he has a fever at night and also at times a serous type nasal drainage. would this be good for something like that?

  101. I’ve just learned of Convenia today and suggested it to my veterinarian when the urinalysis showed white blood cells in the urine. My Veterinarian will inject Convenia in few days. Meanwhile I’m struggling giving her 1/3 capsule (estimate) of 250 mg. Amoxicillin until the appointment date. She was/is semi-feral and lost for nearly 1 1/2 months only to be found severely dehydrated, near death and 2 kg. (less than 4.5 lbs.). Evidently without food, water for that time. Therefore, it is difficult to administer further medications.
    Presently, I am trying to nurse her back to health, although renal failure is possible. Is it safe and successful for bladder/kidney inflammation in an old (over 12 yrs. min.) grossly underweight cat?

    • Convenia has a broad safety margin, but it sounds as if your half-wild kitty may have had a limited diagnostic workup. Is there laboratory evidence of kidney failure, or is that a working diagnosis for your pet’s doctor ( ? Even if funds or patient cooperation kept me from obtaining proper laboratory tests I would feel safe using Convenia in most patients. We wish you luck and thank you for going out on a limb for a feral cat, Dr. Randolph.

  102. My veterinarian gave my 2.5 year old cat Convenia today to help with a fever and possible urinary infection. Blood was not visible in his urine specimen but the lab did come back with evidence of a low number of red blood cells and no cyrstals. His fever was approximately 105 degrees Fahrenheit. What is the estimated time in which I can expect to see my now-lethargic cat getting back to his normal, hungry, mischevious self? Thank you so much for your time! I feel so silly being so worried about this little guy, but he really has come to mean so much to me and my husband!

  103. Dear Dr. Randolph: My cat first exhibited signs of an injury — limping on his right foot — 4 days ago. He then became somewhat withdrawn and lethargic. The limping didn’t persist, but about a day later he vomited 3 times within a 24 hour period. His right leg and paw were still swollen but acted more normal. I took him to the veterinarian yesterday who couldn’t see any puncture wounds but did say that the leg was overall swollen and that is what caused the swollen paw. He administered him a shot of Convenia and some anti-nausea medicine. I’m to take my cat back if his condition does not improve. How quickly should the Convenia start working? His leg is still swollen. Thank you for your answer for the question.

    • Dear Mrs. Grossman,
      I would say the correct question is not “how quickly does Convenia begin working,” because it begins to work in a matter of minutes. As soon as circulation picks up the medication and takes it to the leg, where the suspected infection is, bacteria begin being killed, IF the bacteria are susceptible to that particular antibiotic. As Convenia is a broad-spectrum antibiotic, it kills a lot of different kinds of bacteria. Rather, the question might be, “How long will it be before the swelling goes down?” That depends on how many bacteria are in the leg. The more bacteria, the longer it will take Convenia or any other antibiotic to kill ALL of them. Typically, however, (which is what you really want to know, as much of the preceding is academic) tissues infected with cat-bite bacteria and experiencing cellulitis will improve in 24-48 hours. Of course, every patient is an individual, and every bite, even on the same patient, is an individual case.
      Ask your pet’s doctor about hot-packing the area to improve circulation and speed healing, if he has not already recommended doing so. Of course, he may have a reason he doesn’t want you to do that.
      Please keep us posted on your kitty’s progress.
      Sincerely, Dr. James W. Randolph

  104. My cat has been getting Depo Medrol injections for a reocurring skin problem. Recently she has also been getting Convenia as well. When she started on the Convenia, she has been licking herself so much that she has licked her fur off in all of the areas on her body that she can reach. She is a 2 year old Bombay in otherwise good health. Can the Convenia or the combination of Convenia and Depo Medrol be causing her skin to be dry and itchy? Thanks.

  105. Hi Dr. Randolph: He had the Convenia injection for a severe hot spot. He’s got a sensitive stomach and cannot take oral antibiotics. This is not a coincidence because it happened once before, when he got his first shot of Convenia a couple of years ago. That time it was for an anal sac infection. He does not seem sick; he’s eating and drinking just fine. The stools still have an orange cast, but not as vivid as the first few days after the shot. My dog “Eddie” is a Borzoi and has a very sensitive system. I was worried it might be his liver, but was told by a rep from Pfizer that the drug is matabolized through the kidneys. As long as he’s not sick I’m hoping the sweet potato-colored stool is benign. Thanks for your interest. Bev

  106. Convenia injections turned my dog’s stools the color of a sweet potato.
    Is this common? What causes this?

    • Bev, my first impression would be that it’s a coincidence, or that the disease process for which he was being treated caused the change in stool color. I haven’t seen that as a reported side effect. How long did it last before it changed back to a normal color for him?

  107. Dr. Randolph,
    I’m curious: Does CONVENIA ANTIBIOTIC make animals want to sleep more?

  108. Dr. Randolph, Now I have a a couple questions. Is Convenia good for any animal or just dogs and cats?
    I was told dogs and cats. Can other pets be injected with Convenia if needed?

  109. I took my cat to the veterinarian yesterday and the veterinarian injected him with Convenia.
    My cat is tired and still droopy because when I got him, he was not well to begin with. Anyhow: I Love him. 🙂 This CONVENIA INJECTION – Seems to be working because after the injection, believe it or not, I saw a small but -weight lifted off my sholders-improvement. My cat is still droopy but keep in mind that his CONVENIA INJECTION was only done yesterday. My cat has a MUCH better LOOK about him. If I could only send a picture of before and after on this Web site, then you could see what I mean. So far,this antibiotic is a BLESSING. : ) Hope this helps. I agree with Dr. James. W. Randolph, ASK your veterinarian if CONVENIA ANTIBIOTIC INJECTION is RIGHT for your dog or cat. Have a nice day. GM

  110. My 20 month old Shih Tzu male had been scratching and biting himself so much that he developed scabs on his right hip and the base of his tail (“hot spots”). Since he is already on Sentinel and Frontline Plus (has been for a long time), and we did not see any fleas on him, we assumed it was allergies. I took him to my veterinarian, only to find out that he had retired, and several new young veterinarians took over his practice. The woman veterinarian who saw him treated him by shaving the areas with the scabs and cleaning them, and gave him a Convenia shot. She also gave us Hydroxyzine capsules for the itching, as needed, and a topical antibacterial spray to put on the affected areas, as well as Derma-soothe shampoo and cream rinse to ease the itching. Well, since that visit last Wednesday, my dog has not been the same. He has been acting strange, very lethargic, and is not his usual, playful self. He plops down in one spot and refuses to get up (normally he would be coming to me with his little growling bark to go outside). I have to pick him up and take him outside – once out he will only walk far enough to pee and poop, and then wants to run right back home (very unusual for him – he usually likes to walk for a while). When he gets back home, he runs inside and literally plops down in one spot, and will not move the entire day. I have only given him a total of 3 Hydroxyzine capsules, since I was afraid that might be causing him to be lethargic, and he hasn’t had one for 2 days now, and he is still very lethargic. Could it be from the Convenia? I am so upset – I want my old dog back! Will this wear off?

    • One of the important aspects of medical care for any species, including people, is that we don’t let problems linger and wait too long before we consult our doctors about whether something different should be done. This has been going on since last Wednesday, and that’s too long for lethargy to be allowed to persist. Several possibilities exist: 1, and I put this one first for a reason, when pets get hair removed, a protective covering is taken off the skin and that allows all kinds of sensations to be perceived that weren’t felt before. If your ShihTzu doesn’t usually do this when he’s groomed it’s not the cause, but it’s a strong consideration. 2, The skin is the largest organ in the body and if his skin is infected it could easily be causing him to feel bad. Convenia is a great drug, but it doesn’t kill every kind of infection, so IF the infection is not responding to the Convenia he might need different medication. 3, Hydroxyzine is known to cause lethargy, and it some pets it can be really dramatic. It’s possible that your ShihTzu is one of those. Now, of the three items I’ve listed, two of them require that you see your pet’s doctor for a followup visit. In addition, there are MANY other possible causes of lethargy in dogs, and just because it happened at the same time as this visit doesn’t mean there couldn’t be another problem going on. Please write back and let us know how he is. Best wishes, Dr. Randolph.

  111. Hi Dr. Randolph, My late husband was a veterinarian and we surely miss him. My son had a kitty who showed up on his property in the mountains. He grew there for a few months, and then one day, his brother who was staying in his mobile home while Tay was working in Seattle, moved to a property about 8 miles away. Anyway, Max took the kitty with him and about 15 minutes after he arrived at their new rural home, kitty took off and 3 WEEKS later appeared back at Tay’s property, emaciated; a rack of bones, covered with animal bites which have turned into nasty abscesses. He made it through the night last night and Tay took him to a veterinarian who was open today, July 5. The new wonder drug was used on him, along with IV fluids, sedatives etc. It looks like he will make it. KITTY REALLY EARNED HIS REPRIEVE ON LIFE, and is a wonder he made it for three weeks with limited, if any food and water. Kitty had to go through quite a journey over several canyons, creeks and mountainous juts of rocks and cliffs. We think a wild animal got him, but he’s a trouper. Tay felt so sorry for the poor little kitty he almost used his .22 caliber rifle to take him out of his misery but couldn’t do it as it just wrenched his heart to know what the little thing had gone through for 3 weeks. Thank goodness they have this antibiotic. His veterinarian just couldn’t believe he was still alive.
    I’m writing animal stories about our adventures with my husband and I will add this one to the bunch.

    • Steffy, that will certainly make a great addition to your collection of stories. There are certainly some amazing stories to tell about animals making it back to their original homes. Kitty deserved to have a chance for his life after going through all that just to come back and live with Tay. Thank you for sharing, Dr. Randolph.

  112. Hi Dr. Randolph, Just wanted to give a quick update. The Covenia seems to have given my Annie relief in her ears and 15 days out, her sneezing and breathing are great. Her kidney issues seem to be in balance, for today, she has had about 2 good weeks, little vomiting and only missing the litter box once.
    Not sure if the Covenia helped the kidneys, but she has had good quality of life, playful, eating and sleeping of course. Quality of life is most important to me, for her now. It is and will continue to be a day by day process, but Annie has really taught me to stay in the day, and enjoy every moment with her, and really to live “ONE DAY AT A TIME”~ My Veterinarian says she is my ZEN kitty~ I hope to have her for at least a few more months but only time will tell. Thanks for your support and I will post again if anything significant develops.
    Hopeful in LA,

  113. Hi Dr, I recently took my cat, Bear, to the veterinarian this past Tuesday because I noticed there was blood in his urine. They gave him a shot of Convenia but he is still showing blood in the urine. He is not crying out as if he is in pain, and is still going regularly, even if it’s not a whole lot, but on two occasions he was lying down and urinated a tiny bit while just lying there. He has been given oral antibiotics for this before, once last October and previously in Nov. ’06. I believe I caused the one in Oct. of last year, by changing his food from a food meant for Urinary Tract health (Purina One). Since then, he’s been on a diet of Wellness dry cat food and once or twice a week, the Purina Urinary Tract health wet food – because he loves it so much! I was recently getting away from feeding him this Purina wet food, because I thought the Wellness would take care of his issue. Now it seems I have caused him to be sick again! What exactly is the best food for cats that are prone to this issue? Once I know, I will never ever switch food again! Also, we are taking him back next week for a urinalysis to confirm his diagnosis. But I am hoping the blood in the urine and his urge to go all the time, and outside the litter box will resolve itself sooner. Do you think he will be better tomorrow or should I take him back to the veterinarian before the weekend? Thanks so much for your website. Just reading the comments has helped!

  114. Thank you Dr Randolph. As for Annie’s ears, because of her chronic respiratory/herpes, and recent allergy season, she has been sneezing excessively and has a tremedous amount of phlegm. Not pretty, but a fact of life with a cat like my Annie! When I asked if the chronic renal failure had anything to do with her hearing, my veterinarian said it might, might be from her chronic sinus issues. She looked in to Annie’s ears with a scope and found the ear drums to be “thick” and she said could be a number of things, but probably associated with the sinuses. Because she also sqeaked a bit when the doc tried to look in, (she is normally so stoic) clearly it was painful. The doc said since she tolerated it well once before, and it did give her about 3-4 wks of relief from the sneezing, I said ok. Do you have any additional thoughts we could explore? Thank you in advance. I appreciate your prompt response. Janine

    • I certainly agree that with thickened tympanic membranes, the sinus issue on “the other side” could be a factor. As eardrums thicken they become less pliable and thus less responsive to sound waves hitting them. I completely agree that it’s worth a try. Keep us posted on how Annie responds, please. Our best, Dr. Randolph.

  115. My kitty, Annie 15 1/2 yrs old was diagnosed with Chronic Renal Failure about 5 wks ago. My veterinarian gave her Famotidine (Pepcid), for nausea, daily, Epogen every other day and 100cc of subcutaneous fluids. I am happy to say we took her off of Epogen last night but will continue with subcutaneous fluids and Pepcid. Annie also has had asthma/allergies for the past 10+years. So, because of the flareup of her allergies, she has been phlegm-filled and sneezing lately. I noticed her shaking her ears and told the veterinarian that she wasn’t hearing as well. The veterinarian chose a Convenia injection as a course of action, since she tolerated it well once before. My question, in treating her clearly-hurting ears, will it take to notice some improvement? Is is like human antibiotics, 2-3 days? It has been 14 hours. Thank you in advance.

    • You will find this post informative regarding how we choose antibiotics, the specifics of which are mostly independent of species (human vs. dog or cat). In Chronic Renal Failure (CRF) Pepcid is used for nausea, but more importantly to control ulcers and other forms of gastric irritation that occur secondary to changes in the disease process. Subcutaneous fluid therapy should continue for the life of your kitty, and check with your pet’s doctor about whether the quantity should be adjusted from time to time. Epogen must be used judiciously because, for a variety of reasons, the body can cease to respond to it at some point. Epogen should also be used with careful guidance from your veterinarian. Please tell me more about your kitty’s ears so that I can address them specifically. Standing by, Dr. Randolph.

  116. My 3-year old Siamese was diagnosed with a UTI on Monday and was given Convenia. The urinary symptoms have improved (much less frequent trips to the littler box to urinate), and he’s eating and drinking well. However, he seems much more lethargic than normal and hasn’t had a bowel movement since Tuesday morning. I have a call into the veterinarian, but thought I’d check with you as well. Is it just a stress issue, or is lethargy a side effect of the medication?

    • Erin, I would assume that the lethargy is associated with the disease process, because we don’t usually see lethargy with antibiotic administration. Of course, we don’t administer antibiotics to well patients, we give them to sick patients, many of whom are already lethargic. Certainly if the lethargy persists I would check in with your pet’s doctor to get his evaluation. Best wishes, Dr. Randolph.

  117. Are there situations where this injection is not sufficient as an antibiotic? My Dad’s cat had one for a gum infection. That was 3 weeks ago. Today, she has a fever. Her gums seem okay, but I wonder if somehow either that one shot was not enough or that she needs another type of antibiotic. Drinking water alone seemed to bring the fever down. Could this fever be related to the original infection?

  118. On April 16th, I took in my sixteen year old indoor female cat (Kola) for the annual Rabies and FVRCP vaccinations required by Cook County of Illinois. My cat had been treated for three years for hyperthyroidism with an oral medication. The veterinarian noted weight loss from the previous visit six months prior and recommended a special kidney diet. Blood was drawn at this time. A few days after this visit, Kola started urinating more frequently and more times outside of the litter box. She had received Convenia the previous year for a similar occurrence and it worked well. I returned to the veterinarian and Convenia was administered. After this visit, Kola progressively got weaker and weaker. Another visit to the office was scheduled. The lab work was back and all results were either in the normal range or just moving beyond the limits. The veterinarian could only speculate on the cause for the weight loss and weakness.
    Over the weekend, Kola weakened to the point where she could only lie on her side. She would still take food and water through a syringe. Yesterday, she was virtually limp and I had her put to sleep.
    Was the combination of Rabies, FVRCP, and Convenia injections too close in time? (Four days apart). Kola’s decline was so rapid. I’m heart broken over her loss and whether I did not give her the proper care.

    • Keith we are SO sorry about the loss of your Kola. I know you are heartbroken. If you are a regular reader you know that we, too, have an elderly cat, Martha, who has some age-related problems, and we can certainly relate to how attached we are to a pet we’ve had for that long. Without the laboratory test results and physical examination notes from the medical record I could only speculate as to the cause of death, but I doubt that the injection process was the cause. I won’t say it didn’t play a part, as cats in this age group can be put out of balance for any number of reasons. Our sympathies on your loss, Dr. Randolph.

  119. I have a cat who is about 10 years old. She started having allergy type symptoms with small bumps all over her body about a year ago. They itch and are sometimes painful. Her ears get a little crusty. The only place the bumps do not appear is her tail. She pulls her fur out and leaves it all over the house. Sometimes the skin end of the fur has a little crusty black hard piece at the end of the shaft area. We have taken her to the veterinarian for the 4th time in a year. We have tried a special shampoo (that’s right, try giving YOUR cat a bath!), switching food, cortisone injections (which clear it up for a month and then it comes back) Her appetite is fine but I know she is uncomfortable. We have 4 other cats and they do not have this problem so we know it does not cross-contaminate. She recently received a Convenia injection. We are ready to give her low-dose prednisone daily as that seems to be the only thing that works, but I know this can have secondary effects. Any idea of what’s going on? Help!

  120. Dear Dr. Randolph, my cat had an adverse reaction to azithromycin and experienced swollen paws. Once the swelling went down the pads on his feet became hard. Some skin on his legs has fallen off and scabbed up. The wounds are beginning to heal but the pads are still very hard on his front paws. His right paw the entire paw has hardened like a rock. He is having pain with walking. He has received a couple of Convenia injections and with Epsom salt baths some of the hard skin has come off but his right paw is still extremely hard. Are we on the right course of action for treatment?

    • Tonya, reactions that result in vascular (blood vessel) damage often cause death of tissue such as you describe. Pets, people, farm animals, all are subject to some really disastrous wounds when this type of damage occurs. Your may concern is to maintain antibiotic therapy until healing is finished (continued Convenia injections are fine if he is tolerating them) and you may wish to ask your veterinarian about an emollient to help soften the skin and crusts. Gentle massage can help, as can whirlpool baths IF your veterinarian approves them. Please keep us updated about your baby, this is a heartbreaking story.

  121. Dr. Randolph, he is feeling much better today and has stopped trembling. The wound looks better too. I definitely agree that he was just uncomfortable. He has also been sleeping a lot but I think that is because his body is fighting off the infection. Thank you again for your help.

  122. Is a Convenia injection good for eye problems or irritation?

    • As with any medical condition, whether a certain medication is good or bad for a certain condition depends on the diagnosis and the appropriateness of the medication for that particular diagnosis. That said, I can’t imagine using Convenia alone for an eye condition other than uveitis. Please write back with more information.

  123. Dear Dr. Randolph,
    My kitty escaped from my house 4 nights ago, thankfully he came back the next morning. I checked him over to make sure he didn’t have any bite marks, wounds, etc. While checking I noticed a small lump on his right side, I wasn’t too alarmed and just figured to keep an eye on it. Well, when I came home from work yesterday, the small lump on his side had came open. It looked horrible. I immediately took him to my veterinarian. She said that it was bite from either a cat, raccoon, or rodent (most likely a cat). She prescribed Convenia and told me to flush the wound 2 times a day with chlorhexidine solution. I know my kitty is in immense pain, but he has been trembling ever since I have brought him home and has been acting very skittish, he is normally a calm kitty and actually enjoys car rides. I wonder if his trembling and behavior is a side effect of the shot? I have a follow up appointment in 2 weeks but I want to make sure it’s just my kittie’s nervousness and not a side effect of the antibiotic. Thank you in advance for you help.

    • Kendal, the greatest likelihood is that your kitty is trembling because he is uncomfortable. Of course, there is always the possibility of internal damage that may be causing complications. This is one of those situations where the veterinarian attending the patient will need to make the judgment call whether to dispense pain medication or see the patient for a followup. Please keep us posted.

  124. For Mindy from Ginger: Bless you for your dedication to your kitty. Although right now it’s so hard, time will be your friend. You will recall many joyous times you had with your kitty. The love of a pet is so pure, both ways, that you will never have regrets or guilt. Pets don’t let you down like people do. That has been my experience. My Midnight has been gone just over a year and I am at peace with his passing.

  125. My cat had a shot of Convenia for dermatitis. She had not been diagnosed with anemia before but quickly developed anemia within a couple of days and had to be put to sleep 7 days after the injection because she was so weak. She also seemed comatosed after the first couple of hours of the shot and had tremors. She developed anorexia so had to be force-fed with a syringe. In my opinion Convenia contributed to her death and should be used with extreme caution. I believe it is a useful antibiotic for some people who can’t pill their pet. I knew nothing about this new “wonder drug “when I took my cat for a check up and the veterinarian did not inform me beforehand only once it was already in the system.

    • Dear Marie,
      What a tremendously sad story.
      I am so sorry you have lost your kitty.
      While her death occurred in temporal conjunction with the Convenia injection, I seriously doubt that Convenia was the cause, although it is not impossible.
      There are many, many, many possible causes for anemia that I would put on my differential diagnosis list before Convenia.
      I would encourage you to file an adverse-reaction report with the manufacturer:
      I know that veterinary practice is probably somewhat different in England compared to United States practices, but the patients are the same, and the hurt we feel when we lose them is the same.
      Please accept our sympathy for your loss, Dr. Randolph.

  126. Hi. This will be my final update. I had to put my baby girl down today. She was just too weak. My heart is breaking into a million pieces. I think her sister senses she is gone. I hope she does ok. I will have my baby’s ashes by Tuesday or Wednesday. That’s going to be hard, too. I just don’t know how to continue without her. But she went peacefully. I just hope she wasn’t mad at me. I couldn’t handle knowing her last thoughts while looking in my eyes were of her begging me not to do that to her. I do appreciate your advice and information these past few weeks. It really helped.

  127. Hi. I was back to the veterinarian today for a checkup and wanted to give you an update.
    It’s really just a day by day thing. Just need to make sure she is eating and keeping it down. I think giving her the subcutaneous fluids helped. She hardly made a sound on the way to the veterinarian, but she was mostly definitely vocal on the way home lol
    The doctor gave her an enema and she had a nice poop. Wasn’t really a lot in her i don’t think, but hopefully that was all she needed to feel better. She was throwing up so much yesterday and last night that I was terrifed to go to the appoinment today. I’ll be taking her in once a week to have IV of fluids which will help keep her hydrated and eating.
    She hardly ate anything at all last night but when I brought her home she finally ate and had a little sleep.
    There is definitely a lot of weight off my shoulders today. The only thing is that the injection she got last Saturday stays in her system for 2 weeks, which means this Saturday will be her last day. So it’s really going to be a waiting game after that…but the doctor said I can give her a little tiny bit of Pepcid which would help with her upset stomach if she still urges to vomit.
    To make matters worse I came home yesterday and her sister was sick. Constipated to be exact…so I was cleaning up vomit all day yesterday when I came home. How lovely for me lol
    So, needless to say there was a big relief when I came home this afternoon. Just gotta keep my eye on her.

  128. Wanted to provide you with an update. Had her to the veterinarian yesterday and every test imaginable was completed. Unfortunately it’s not good news. She has a mass on her bladder that is causing her to frequent the litterbox and the reason there is blood appearing after she urinates. She has lost about 75% of the function of one of her kidneys and all I can do at this point is keep her comfortable and make sure she still eats. I probably don’t have much longer with her. I take her back for a check up on Wednesday and have some more fluids put in her. All I can do at this point is try to help her the best I can at home but I think her body is slowly shutting down. She spent most of the night last night in the closet on a blanket. Could have either been because she had a rough day at the veterinarian or it’s her way of saying it’s time to go. My heart just isn’t ready for that yet, but I won’t let her suffer either. Thanks for all the help and advice over the last couple of days

  129. Thank you for the reply. I did want to add another question. Would it be beneficial and advisable to get her on some special food for urinary tract health? Would this help to alleviate any trouble she is having with her urine?

  130. My cat had this shot last June and it worked WONDERS..she was urinating all over the place and I never realized it until I caught her with my own eyes. Well, a few days ago, she was back to the same thing….but this time it seemed a bit worse….she was throwing up…meowing all over the place (in pain), passing very little urine, drinking a lot…took her to the veterinarian on Saturday..there was blood and white blood cells in her urine…veterinarian gave her the shot again…she seems to be doing much better BUT, she is still passing little urine, and is still frequenting the litter box more than she should. Am I worrying for nothing and just need to give another day or so for the injection to be in effect? Or could there still be an issue?

    • Mindy, there are myriad reasons for your kitty to have difficulty with the urinary tract. In cases like yours, where small amounts of urine have been passed, we sometimes have to begin symptomatic therapy on the assumption that there is infection, when, in fact, there could be causes of inflammation unrelated to infection or infection that is complicated by other factors. You have inspired me to write a piece about this very complicated topic, and I anticipate posting it this Friday. For now, give your kitty another day or two, but if she isn’t doing better soon she will certainly need a followup visit to your pet’s doctor.

  131. Just thought of one more question. another veterinarian has theorized that feeding cats the diet that is natural for them – lots of meat, could help a lot of felines feel a whole lot better. it makes sense that cats’ bodies evolved on a high-protein diet and that us inadvertently giving them far too much carbs is causing our fluff-balls all sorts of needless suffering. Just like how us humans are eating too many carbs, too, and suffering for it with diabetes and etc. Thanks for your thoughtful replies.

  132. Would it be a problem giving Fluffy her beloved daily dose of plain yogurt while this shot is doing its job? I’ve heard about problems with some antibiotics and all the healthy bacteria in yogurt. Thanks.

  133. I recently got a Chorkie puppy who had severe itching. He was losing a lot of hair and the second day I had him the doctor gave him the shot Convenia. He wasn’t moving or eating much but I thought maybe this was typical of him since I hadn’t been his owner for long. Three days later he could not walk or even stand up. His legs were wobbly and his eyes were “lost.” He had to get 2 blood glucose sticks as well as Karo and the veterinarian told me he probably wouldn’t make it. I had to feed him every few hours and also give him a nutritional supplement. Finally after about ten days he started acting like a puppy again. Now over a month later he has scaly stinky skin and had previously been diagnosed with sarcoptic mange. I am going to take him to the veterinarian again but am afraid they are going to administer Convenia again.

    • The good news, Jennifer, is that it wasn’t the Convenia that made him hypoglycemic. The most likely cause is an inherited predisposition from his Chihuahua heritage. Hypoglycemia is very common in that breed. Yorkie puppies are also predisposed to hypoglycemia, as well as shunts in their livers, which can cause severe illness. The other good news is that Scabies, or sarcoptic mange, in dogs is usually easy to treat. In resistant cases there are alternative medications that can be used. Scaly and stinky WITHOUT itchiness probably isn’t Scabies, but still needs investigation and treatment, so don’t delay taking him to the doctor. Scabies is sometimes transmitted to people, so be sure to let your physician know your puppy has Scabies if you become itchy.

  134. My 5 year old male cat suffers from Urinary Tract Infection. It recurred 3 times in one year. In August 2009 he was diagnosed with UTI and he got medication and antibiotics, then 2 weeks later it recurred. I took him back to the veterinarian and she gave shots and antibiotics and he was on a special diet (Royal Canin) for around four months from August to November and I noticed that he lost weight so I switched back to commercial pet food: Whiskas and Purina. Yesterday I saw him straining and something white is coming out with tiny drops of urine. I think UTI recurred and I will take him to the veterinarian tomorrow as it’s the weekend now and he is closed. I am so worried about my cat especially we don’t have specialist veterinarians in my country (I live in the UAE). All of the veterinarians are telling me to just feed him Royal Canin but its not working out. Please help my cat 🙁

    • Azza, it sounds like to me that the Royal Canin was doing its job, and that the problem only relapsed after you changed foods. For those cats who create struvite crystals in the urine by concentrating magnesium, ammonium and phosphate ions in the urine, I have seen a SINGLE MEAL of the wrong food create a relapse. If he is losing weight on Royal Canin but maintains a healthy weight on other foods, ask your pet’s doctor whether he can just eat MORE of the Royal Canin. That should solve the weight issue AND the urinary tract problem. IF there are future problems with the urinary tract, please ask your veterinarian to culture the urine to determine whether there ACTUALLY IS infection, or whether the bladder wall is inflamed from crystals, or possibly idiopathic cystitis.

  135. Dr. Randolph, Exactly one month ago I played with a sick kitten with distemper. I wasn’t worried because my cat was vaccinated 11 months ago. My 3 year old cat started hacking yesterday, but nothing came up. Didn’t think much of it, since she vomits hairballs about once a month. Today she showed other symptoms such as not eating or drinking, acting sleepy, slightly closing one eye, walking around very slowly, but otherwise staying in one spot. I fed her water and gravy from soft food through a dropper 2x today. Could she have contracted distemper or another disease from my clothing?

    • Carolyn, cats don’t get distemper, it is a disease of canids (dogs, wolves, coyotes, racoons get it, too), but what is sometimes mistakenly called “feline distemper” is actually Panleukopenia. That doesn’t sound like what your cat has. It is easy for fomites (objects can transmit a disease without modifying it or otherwise playing a part in its progress), such as clothing or your unwashed hands to transmit any of the several upper respiratory diseases cats get. Because some of these can be serious you should obtain an appointment first thing Monday so that your cat can receive a proper diagnosis and the correct treatment. Remember, too, that there are diseases we cannot vaccinate against, so your kitty is not immune to every disease there is, only the ones we vaccinate against and the ones she gets “community” immunity to.

  136. My 3 year old cat has recurring Urinary Tract Infections. Two days ago, she starting getting ill–lethargic, not eating or drinking, not urinating–so I took her to our veterinarian yesterday. Her temperature was 105; the culture results showed she had a bladder infection, and the veterinarian gave her a Covenia injection, a cortcosteriod injection, and injected water under her skin. My questions are: Since it appears that we never quite get rid of the UTIs (since they recurr within a few weeks), should I take her back for another culture? If so, how many days after the inital visit and injections should I get another culture? Should I ask the veterinarian to start an oral antibiotic regimen after the 10 days of Convenia coverage? My cat will take pills. It’s been 24 hours since the Convenia shot, and she is not noticeably better. Two weeks ago, when she was given oral antibiotics (Clavamox 62.5 mg.) for a UTI with 105.9 temp, she was nearly back to her old self within 24 hours. Thank you for your help.

    • There are several things that concern me about your kitty’s recurring UTIs.:
      1. Whenever UTIs recur we become concerned that there is an underlying cause, such as bladder stones (these are not always palpable, sometimes an X-ray, or even a double-contrast X-ray, or cystoscopy are required), bladder wall defects, such as persistent urachus (a defect from birth) or even tumors of the bladder.
      2. How long is she taking medication? If I use Convenia for a urinary tract infection I typically repeat it in 2 weeks, giving the patient a full month of antibiotic therapy.
      3. If using oral therapy I like to give a minimum of 3 weeks of therapy.
      4. That your pet’s doctor is culturing the urine means that he knows which antibiotics will work best. It’s possible that she just needs to take the right antibiotic longer. For recurring problems I’m not afraid to use an antibiotic for a couple of months, if it’s indicated. Sometimes an antibiotic is effective in the laboratory, but not in the body. Use of a different antibiotic from the list, for an adequate time period, may help.
      5. Other underlying problems can include not cleaning the litterbox frequently enough (twice or more daily is NOT too much!), folds around the vulva that predispose to holding infection, inability to hold a squatting position and keep vulva from contacting the litter (unlikely in a 3-year-old).
      If your veterinarian is unable to perform the tests listed in (1), he can refer you to a specialty practice where those can be done. For example, few general practitioners own a cystoscope.
      6. Few feline patients spike fevers so high with uncomplicated lower urinary tract infections. Her kidneys may be involved. You need to take her temperature at home a few times with her well, and the next time she’s sick, before taking her to the doctor. Some patients raise their body temperatures from the excitement of going to the doctor.
      7. What are the results of her CBC and Chemistry Profile?

      These are major points, there are some less-likely possibilities, but it provides you with a strong starting point.
      Please do keep us updated on your kitty and her response to therapy. We will be eager to learn how she does.
      Best wishes,
      Dr. Randolph

  137. My veterinarian wants to draw blood yearly (CBC/Chem 11) from my indoor cats, ages 1 to 1 1/2 years old. Is this necessary?

    • Dear Karen,
      The answer to this question really comes down to what level of care you want for your pets and what you can afford. I commend your pet’s doctor for wanting to do what’s best. Are your pets at high risk? Probably not. Are they of breeds that might have a predisposition to certain problems, such as Persians with a genetic tendency to PKD? If there are predispositions your veterinarian should be able to explain those to you. At some point, probably around 5-7 years of age, he will want to add a thyroid test to the panel, as cats in this age group may begin to develop overactivity in the thyroid glands.
      What percentage of cats will be helped by this program? Probably a small percentage. BUT! if it’s your cat, or your favorite cat, and he detects abnormalities early, you sure will be grateful for the testing. As I always say, if we knew the test results, we wouldn’t need to run the tests, but we can’t tell by looking which cats, or dogs, are harboring subclinical health problems.
      Many, many pets whose problems are caught early will benefit in terms of degree of success of treatment and longevity.
      Bottom line? If you can afford it, by all means do the tests. If you can’t, save up for next year’s tests, and plan ahead to have the funds available for each successive year.
      Thank you for the question and for your readership of,
      Dr. James Randolph

  138. My 9 year old cat, Lotus, has suffered from chronic upper respiratory infections for years. She has been treated with several different medications, some of which caused her to vomit. When my veterinarian finally found one that she could tolerate (Orbax), it helped while she was on the medication, but the symptoms (thick yellow discharge from her nose, sneezing, gulping and struggling to breathe) came right back right after she had finished the medication. I recently heard from a friend about Convenia. Lotus was given the injection 2 weeks ago, and is still doing fine. Her nasal symptoms are completely cleared up and she’s gained a little weight which she needed. This treatment has been a Godsend after years of seeing my little girl suffering and not being able to help her. I realize that she will probably have to have these shots periodically, but to find something that helps her is such a relief.

    • It is understandable that Lotus is still doing well 14 days after her Convenia injection because it has a 14-day duration of effectiveness. The real test will be how well she does after the medication is no longer in her system. What diagnostic tests has Lotus had? Some cats with chronic problems like this are infected with Feline Leukemia Virus and/or Feline Immunodeficiency Virus (you may search for each of these terms on any page of for articles on the topics). Some have polyps or other obstructions to sinus drainage flow. Foreign bodies, such as blades of grass or other objects can cause chronic reactions such as you have described. Such problems may be easily diagnosed by use of a tiny scope passed into the nasal passages of an anesthetized patient. Commonly this is done at a referral center your pet’s doctor can send you to. In cases of chronic viral rhinotracheitis virus (which we will have a post on in the next few days to weeks) some patients improve with immune system boosters such as Enisyl. Best wishes, Dr. Randolph.

  139. My 13 year old dog has been urinating constantly both inside and outside the house. He takes a very long time to urinate and he seems to be straining a lot. I took him to the veterinarian on Tuesday and he received a Convenia injection. It has been 4 days but there seems to be no signs of improvement. How long does it take to see any improvements?

    • Pam, let’s start with more information: 1) Did your dog have a urinalysis and, if so, were there bacteria seen? 2) Was his prostate palpated and, if so, was it normal or abnormal in both size and shape? If it was abnormal, I need to know all the ways it was abnormal. If you don’t know the answers to these questions your veterinarian can supply them.

  140. Hi Dr. Randolph,
    My cat Ernie went to the veterinarian today because his paw pad appeared to be infected. The veterinarian said it appeared to be the result of a cat bite from his brother (the only two animals in my house). He did try to get some pus out of it but not much came out. He received an injection of Covenia. How long until I should expect results on his paw pad? On a side note Ernie appears to be REAL tired tonight, is that a natural reaction? I suppose that long with the stress of actually going to the veterinarian didn’t help either. I just noticed him eating and he used the litter box about an hour ago, just not quite his normal self.

    • Ernie is a sick kitty, so we wouldn’t expect him to be himself for a few days. How long until he is “himself” or “normal” again depends on the type of bacteria in the wound, his body’s immune system reponse to the infection and how long the infection was there before treatment began. Did the doctor instruct you to flush the wound? If not you should at least press gently on the area twice daily and try to get out any pus that you can. Hotpacking the area would help bring healing circulation in, too. If Ernie did not have a Feline Immunodeficiency Virus test, he should.

  141. My cat Howie (domestic long hair) seems to get upper respitory infections alot. My veterinarian treats him with rounds of Amoxcicillin and Vyralis (sp)?. The symptoms always seem to go away and come back after a few months. Now he is on shot of Convenia and the amoxcicillin. He lost his appetite and had to have fluids administered. I just do not understand why he keeps getting relapses after all the treatments I give him with the immunity boosting gel. He is an indoor cat only. Any suggestions?

    • Howie probably has a chronic infection with Rhinotracheitis virus. As it is a herpesvirus and the body’s immune system never completely clears it, infected cats are predisposed to relapses. You may also want to have investigated the possibility of foreign bodies or growths in the nasal passages. Convenia and Amoxicillin are commonly-used antibiotics for this, but there are some high-powered antibiotics your pet’s doctor might also choose to use. They can be pricey, but may give you a longer time period between relapses. Of course, we must always keep in mind that antibiotics kill bacteria, not viruses, so IF he has chronic Rhinotracheitis he will always be predisposed to relapses. I have assumed that Howie has been recently tested for FeLV and FIV (you can search for these on for in-depth explanations) and tests must always be paired: two tests that agree, positive OR negative, two months apart. Cats infected with either one or both of these immunosuppressive diseases will be predisposed to URTIs as well as other chronic, relapsing health problems.

  142. Hi,Dr.Randolph,
    My cat, Money, is about 4.5 years old. Few weeks ago, after she came out from the litter box, I saw some light brown liquid on the floor and it had very bad smell, very stinky. I took her to the veterinarian and the veterinarian said she “might” have a lower urinary tract infection and gave her one injection of Convenia. The veterinarian told me if she didn’t get any better within 10 days, then I would need to take her back for urinalysis. It’s been 3 weeks since she was given the injection. This morning I found few drops of brown liquid (a little bad smell) on the floor after she used the litter box. I don’t know if Convenia worked 3 weeks ago but now she has the infection again? Should I take her back for another Convenia? Is urinalysis necessary before antibiotics or treatments are administered?
    I add a lot of water in her cans, so she drinks a lot of water. She urinates more often than another 2 cats I have with the size of urine clumps between golf ball and baseball size. Is this normal? The amount of her urine each time is not much, can it be because she urinates more often?
    Thank you very much. I am very worried.

  143. Hi Dr. Randolph. I have come across your website while doing research on Convenia. My cat, Wiggy, was treated for blocked urinary tract (struvites) in Dec. ’08. I refused the Convenia because it’s new and long term side effects unknown (this was pre-blockage). A few hours later he was admitted because he became totally blocked. He was given Convenia (against my wishes) during his course of treatment as he is too aggressive at the vet to do oral administration (I would have done it). But anyway, it is nearly a year later and my cat is somewhat better since the spring but overall, has not improved past a certain point. His bowels have never recovered from the antibiotics (he had a round of Clavamox in April as his pH became elevated and we were afraid UTI was recurring). While he does not have consistent diarrhea, his stool is mostly loose, sometimes liquid, occasionally solid. He is somewhat weakended in his motor skills – jumping calculation and such and his hind end seems a little stiff (and also it seems when he sits, he does not sit all the way down – bowel related?) My main concern is his weight. He has remained 1 to 1/2 lbs. underweight since June. He is on probiotics, essential fatty acids, milk thistle (for slightly elevated liver panel) and will be getting digestive enzymes starting today. He is on food prescribed by my vet (Iams Intestinal Low Residue – which I consider sub-standard) as this seems all he can tolerate (Solid Gold, what my other cat eats, gave him diarrhea). He also gets canned food (Wellness) – which though he needs the moisture, I think is partially responsible for keeping his stool soft as when he was on dry only, his stool was solid much more often). He eats well most days. I have gotten the cats a water bubbler but they still prefer the tub. As of Aug. ’09 his ALT was 286 U/L and T4 = 2.0. I have also just discovered (today) in reviewing Wiggy’s records, that in December, when he was having his catheter removed, his heart stopped twice and he had to be intubated and given CPR. I was never told about this and am highly upset to discover this via notes. The notes prior to cardiac arrest are as follows: “Tanlad down w/ Iso. [??] Removed sutures and u. cath. Rx: Buprenex 0.2 cc IM. Started to admin S0F when cat’s heart stopped.” The first line I do not understand. Also unclear as to why my cat’s heart stopped (this was not his first exposure to Buprenex).
    I am really at my wits end with my vet. I live in a small town, there are no holistic veterinarians here and all my vet wants to do is give my cat more drugs or is generally lax about follow up. In general, she seems to have no clue what is going on. Taking my cat to the veterinarian is highly stressful for him – more so than is usual. Just getting his blood is terribly stressful. He is a fighter. I know he likely needs more bloodwork.
    Any direction you can shed would be most appreciated. I am willing to give my cat drugs if they are helpful, I am not willing to medicate him needlessly and with shotgun diagnosis. I just want him to be well, not do things that make him sicker. I am willing to pay for phone consultation if you think it would be more condusive. Thanks for putting your time into this website.

  144. Dr. Randolph:
    My nine year old cat Ella had an injection of Convenia on 11-24-09 I took her to the veterinarian because she was sneezing a lot. No temperature and was eating normally. I have another cat Louie who is 4 years old. They like to go outside on a leash when it is nice which in South Carolina is a lot of the time. We have been away recently so they haven’t been out as much till last week. Ella also got a Depo Medrol injection on the same day as the Convenia. She seemed fine till today and the sneezing is back again. Our vet is out till Monday Nov. 30. She is eating and using the litter box. Should we see results from the meds by now? Last January Ella had urinary infection treatment with antibiotics and is on Hill’s Prescription Diet C/D multicare food for cats now. Also she gets Dasuquin which is supposed to help with decreasing crystals which she had on urinalysis. I am due to go away again and a close friend pet-sits for me. The chest is clear. Any thoughts here would be appreciated.

    Jennifer A. Stoops

  145. My 9 year old Lab has severe skin problems, sores and itching. Would this drug help him?
    Thank you, Peggy.

  146. My cat was diagnosed with a UTI today and given a Convenia Injection. How long should it take to notice improvement?
    Appreciate your advice,

    • The length of time to improvement depends on the initial presenting signs and the urinalysis findings. If he initially presented with straining to urinate and blood in the urine it could be several days before those aspects are resolved. If the bacteria were round (cocci) as opposed to rod-shaped (bacilli), we woud usually expect faster improvement. We hope your kitty is doing better real soon. Keep us advised, Dr. Randolph

  147. Well now I have taken my dog out of PetSmart and into a pet hospital where he is in intensive care. They have given him a SNAP test, critical care exam, tick borne PCR, ultrasounds, Xrays, pain medication, an MRI but had to wake him from the anaesthesia because he was short of breath. The only thing they know for sure is that his pain is coming from his back and neck which a neurological specialist feels that it could be neurological. He also has abdominal pain and his ribs hurt on his left side. They have told me that tomorrow they want to run more Xrays on his abdomen to see why he’s in pain even though PetSmart has taken those Xrays prior because they said that maybe there will be a changein the Xrays. Other than that they said that he is responsive, has been eating, and does not have diarrhea but is on pain medication. Was not able to see him on the weekend because they don’t allow visitation on the weekend. I will see him tomorrow and my bill is up to $6000.00… I am frustrated and I am running out of money. I love him dearly and do not want to lose him because of money.

  148. Hi, I’m looking for some answers for my dog Marley. He is a Yorkie that weighs 11.60 lbs. He had 2 skin masses that were to be removed today, Thursday at 7am at Banfield. The gave him a shot of Convenia (80mg/ml) yesterday at 6pm… By 10 pm. my dog was acting rather strange. He looked doped up and was shaking. By 3 am. he could not stand on his 4 legs and kept falling over. I took him to Banfield today at 7am. and they have been running all sorts of test (Blood work, x-rays, checked his bladder, and now have administered pain medications) and have found nothing. My bill is up to $500.00 and they need to run more tests. My dog is 7 years old and will be 8 in dec….. Do you have any advice before I have a nervous breakdown?

    • There are a jillion possibilities, which is why the doctors at Banfield are running tests and taking radiographs. It could be a quirk of his response to the anesthetic, or a change in his demeanor and metabolism as the anesthetic wore off. I doubt that Convenia is a factor, as we might expect vomiting and loss of appetite if it were, but not shaking and ataxia. Without the test results I can’t help much, but I would certainly be interested in knowing what the doctors find and how he is recovering. By the way, 8 is not old for most Yorkies.
      Best wishes,
      Dr. Randolph

  149. My kitty had a shot of Convenia yesterday morning…She has not been eating, and sleeping all the time and had a fever…it has been about 30 hours and she is no better.

  150. My Puggle Herkie got a shot of Convenia last Wednesday, and after that he got a fever. I was wondering if it’s a side effect of the shot. The fever comes and goes but it’s been 3 days already. I am just worried. We went to Banfield 3 weeks ago because Herkie got stung by a bee and his lower lip got swollen. The oral antibiotics didnt work so we when back and they gave him Convenia. I hope he will feel better and the swollen lip gets better.

    • Joanne, several things about poor Herkie’s story bother me. No, fever is not a side effect of Convenia. How HIGH is the fever? A swollen lip from a bee sting should resolve in less than 3 weeks, usually in a day, certainly by three days. There may be a complicating factor, such as the stinger still being in place, OR the bee sting was a coincidence and the REAL cause of the swelling is something else. I would recommend that you either take him back to the doctor for more aggressive diagnostics or seek a second opinion. Please keep us posted on Herkie’s progress and findings.
      Dr. Randolph

  151. My cat was diagnosed with a UTI and blood in his urine. I took him in Wednesday to get a shot of Convenia since I could not get the oral medication into him. Now he can barely walk a few steps without wobbling and falling over and crying in pain. Is this something to be concerned about or is it normal after an injection? How concerned should I be that he is not eating or drinking. This started on Sunday and he has only eaten a few bites since then.

    • “Is this something to be concerned about…”
      Yes, Julie, you should be very concerned. Your kitty should have seen his doctor on Monday with these signs, as he may have an obstructed urinary tract, adverse reaction to medication or other complication. I will send you an e-mail as soon as I finish this reply, recommending you take him to your local emergency hospital tonight. Please write back to let us know how he fares. This is very serious.

  152. My dog was originally diagnosed with kennel cough. Her symptoms of coughing, sneezing, moderately hacking, retching, gagging, lethargy, depression, spaced-out, no interest in much, poor appetite continued for a month and to this day now almost going on two months. Then I went to a specialist. More chest X-rays were done, and they concluded bronchitis. Previously she was given oral antibiotic that she continuously threw up. They consisted of, Azithromycin and some other one that I can’t think of the name of at the moment. They said since her reaction to oral medication wasn’t going well she was given this injectable antibiotic, Convenia yesterday. This morning she threw up all her food, and my first thought was “Oh no, it’s happening again…intolerance to an antibiotic. She is so weak and has lost a lot of weight. I was having high hopes that this treatment would work and help kill the infection she has. Although, would this even knock out an infection such as bronchitis or kennel cough? They say her lungs are inflamed. Second, do you think this symptom of throwing up her food will go away? She desperately needs to put some weight on!
    If this injection doesn’t work for her, what are my alternatives to get rid of bronchitis? Please help, she has felt so bad the last two months, and I know she is running out of time. The poor girl has to be picked up and taken to the bathroom because she is too weak to walk. Any information would be greatly appreciated.

    • Misty, that your dog was initially diagnosed with “kennel cough,” (the proper term is infectious tracheobronchitis (ITB), because the vast majority of so-called “kennel cough” patients have never even seen a kennel) is not surprising. I will cover ITB in an upcoming post. It’s a common condition and all of the signs your pet exhibited fit the syndrome. The vast majority of such patients respond to therapy, resolve, and do fine. Your dog, however, seems to have more than just ITB going on.
      1. There may or may not be infection in the airway, and the only way to know is by tracheobronchial lavage (sometimes called transtracheal wash) followed by cytology and bacterial culture and sensitivity. Was this procedure done? What were the cytology results? What were the culture and sensitivity results?
      2. “lungs are inflamed.” Strictly speaking, lungs are not involved in ITB, or pure bronchitis. A cause for the inflamed lungs needs to be determined and this may require lung biopsy.
      3. In FDA approval trials about 5% of Convenia-injected patients experienced vomiting and loss of appetite. Read the above-linked post and you’ll better understand what those numbers really mean.
      4. “will the symptom of throwing up her food go away?
      a. Your specialist (whom, I assume, is a board-certified internist) is probably considering the possibility that there are gastrointestinal problems, separate from the respiratory tract problems, that are causing the vomiting.
      b. He is likely also considering an intravenous (IV) antibiotic, though even this route may cause vomiting.
      5. That your pet is “too weak to walk” is a grave sign, which I assume the specialist is addressing aggressively.
      Please keep us posted on your pet’s progress, and our readers and I will be eagerly awaiting the outcome.
      Best wishes,
      Dr. Randolph

  153. My 15 year old female cat stopped eating so the veterinarian did a geriatric blood panel. She was diagnosed with high liver enzymes – AST is 172 and ALT is 495. They did an ultrasound and found a probably benign cyst in her liver. We tried Denamarin and oral antibiotics. They didn’t work, but one day she had an injury to her paw – probably bitten by another cat-and the veterinarian gave her Convenia. That was over two weeks ago and now she eats well and seems to be feeling much better. We haven’t tested her liver again because she’s doing well. Do you think the Convenia cured her?

    • Meryl, this is a real chicken-and-egg question. Which came first, the liver problem or the loss of appetite? We will never know. When cats stop eating their livers undergo a unique process that doesn’t occur in all species…the liver begins to suffer storage of fat. The fat then slows down the movement of bile through the liver, which can elevate liver enzymes and cause inflammation and death of liver cells. The combination of Denamarin and other SAM-E neutraceuticals with antibiotics is a common and accepted method of dealing with liver disease when a liver biopsy is not practical or available. IF the liver problem was caused by INFECTION and the infection was not sensitive to the oral antibiotic(s) used but WAS sensitive to Convenia’s ingredient, Convenia might be able to take credit for improvement. The first antibiotic(s) might have knocked down the infection and Convenia finished it off. Or Covenia knocked it down enough that she is no longer clinical. Does that mean she is cured? Maybe, maybe not. Another set of blood tests (with CBC and differential along with the chemistry panel) would tell you more, and a liver biopsy would tell you the most. Do you want to subject a 15-year old well kitty to a liver biopsy? I probably wouldn’t, unless she relapsed, but it’s the only way to know exactly what’s going on in the liver. Please write back when you have the followup lab test results.
      Best wishes,
      Dr. Randolph

  154. Hello Dr. Randolph,
    I have a very beloved 6 year old foster cat, Malachi, who has been in renal failure since birth. He has recently developed his 2nd antibiotic resistant infection this year. The first followed a bad tooth abscess and spread to his sinus cavity. He had no response to Clavamox, Clindamycin or Baytril. Eventually Azithromycin worked. This time his veterinarian sees no oral issues, it just seems to be a sinus infection with much swelling around the nose/eyes and bloody discharge. Azithromycin has not worked and on Tuesday he got a Convenia injection. A day and a half later I see no improvement. Should I wait? Request something else? I very much appreciate any advice you can give me. Thank you, Andie

    • Thank you for your very difficult question, Andie. Clearly Malachi has immune system issues to go along with his other problems. Chances are good that he has a viral component to his nasal discharge and immune stimulants such as Enisyl may help. For the bacterial component of the infection (if, indeed, there is one) the BEST approach is bacterial culture and sensitivity test. Malachi will need to be off his Azithromycin for a few days, then a sample taken, after which he can restart his Azithromycin until the results come in, about 3-10 days. The sinuses may have to be radiographed and/or ultrasounded to determine whether masses are impeding natural flow of normal fluid production from the sinuses’ linings. All in all, it’s complicated, and could be very expensive. Please keep us updated and let us know how Malachi fares. Thank you for your question and your readership of

  155. My 15 yr. old cat developed horrible sores on her eye lid, as well as swelling inside her nose, distorting her face a bit. Now, she’s got a large ball on her mouth. They assume it’s tumors, with possible secondary infections, but they’ve been giving her Convenia and now steroids too. This actually has helped with the swelling and issues, with always come back. Should I continue to give her the meds, a 3rd time. Is it even more dangerous to her to do that?

    • There is unlikely to be any harm to the palliative therapy you’ve described. Convenia makes it easy to have ongoing antibiotic therapy without having to hassle her with oral medications. The corticosteroids may give some reduction of size of the tumors. Of course, I’m sure you are aware that none of this is going to be curative. The lesions sound very invasive, which, I assume, is why you and your pet’s doctor have chosen a palliative approach instead of a more aggressive approach.
      Best wishes with her, and please keep us informed of her progress,
      Dr. Randolph

  156. I moved to a new state a few weeks ago. I took my cats to their former vet before we left for a routine visit. Their vaccinnations were updated and other than needing teeth cleanings sometime soon, all was okay with their exams. Since we’ve been in our new home, one of them has been lethargic and losing weight. I’m not sure she’s eating. I took her to the vet this morning, where they said it could be stress, a virus or her kidneys or liver. She is at least 8 yrs old, but maybe older. She wouldn’t let them take blood. He gave her injections of Convenia and Dexamethasone, and said to isolate her from my other cats to better monitor her water and food consumption, litterbox and any vomiting (which there has been none of so far). He said if she’s not improved in a day or so, bring her back, and they will knock her out with gas to take blood. He said the condition of her teeth was not bad enough to cause her not to eat. She and all my cats have been informally diagnosed with feline herpes, but none of them are exhibiting symptoms right now of that or respiratory problems. She has a fever. All my other cats are healthy, and they are all indoor cats. Do you have any other advice? Thank you!

  157. Hi Dr. Randolph…
    My kitty (2 yrs old) was diagnosed with an upper respiratory infection just last night. He was given a shot of Convenia for the secondary bacterial infections and a shot of anti-inflammatory. Last night he had some vomiting. I don’t want to be an alarmist and call the vet again so soon. Would some vomiting be typical? (All his vitals were ok last night and he was not running a fever.
    Also, upon reading about URTIs, it sounds like he would have had to be around an infected cat to catch this. He is in a single-cat household, outside during the day and brought in at night. I am just wondering how he got it.
    Thanks for any insight into this.

    • Thank you for your questions, Carol. Vomiting is common in upper respiratory tract infection cases as the inflammation of the trachea, pharynx and nasopharynx often stimulate gagging, which leads to vomiting.
      As to where your kitty got the infection the answer is in your question, “outside during the day.” He may have had even passing contact with an infected cat (and the infected cat may be asymptomatic). Feel free to write back if more questions arise, and NEVER be hesitant to call your pet’s doctor’s office…that’s what we’re here for!

  158. Two of our cats have used Convenia with great results after surgery or with infections. Does Convenia work on URIs? I only know that the cat I’m volunteering with is sneezing and coughing a lot. There is a discharge of mucus and a little blood when he sneezes. Does Convenia work on secondary infections from viruses, such as lung infections?

    • Officially, Convenia is approved for use in skin infections. The cephalosporin family of antibiotics has great use in killing bacteria in and on the skin. I have used Convenia twice in upper respiratory tract infections in cats with good success, but twice does not a clinical trial make! By definition, “lung” infections don’t qualify as UPPER respiratory tract infections and I haven’t tried Convenia on pneumonia. Thank you for caring for God’s creatures through your fostering efforts. Best wishes and thank you for your question and your readership of, Dr. Randolph.

  159. My dog was given Convenia yesterday for infection. Later we discovered she had ingested warfarin. Had blood transfusion last night, got her blood to clot, extremely dehydrated this morning, and CBC showed her WBC at 40000. He is putting her on another antibiotic. Shouldn’t the Convenia have kicked in by 24 hours? Her lower lung was full of blood and the xrays this morning showed some improvement.

  160. My cat has been acting strange for 3 days: vomiting, eating less, staying in for long hours, cleaning his bottom more often usual. The vet today has taken a blood sample and administered Convenia. Unfortunately I have not been able to talk with the vet as she went into surgery, immediately after.

    Any thoughts on what may be wrong? I am having anxiety as I wait for the vet to talk with me later today.

    Thanks for your help.

    • There are literally thousands of possibilities, and only the doctor who has examined and evaluated your pet should comment on those possibilities. Unfortunately, emergencies happen and sometimes pet owners are inconvenienced in having to wait for the emergency to be handled before getting the rest of the answers. Please, do write back and let us know what the doctor told you.
      Thanks for reading,
      Dr. Randolph

  161. My cat was acting odd, meaning she wasn’t eating like normal and she seemed to be wobbly some when she walked. She also has an infected eye. I took her to the Veterinarian and he checked her temperature which was normal. He gave her an injection of Convenia which I’m not familar with. She really didn’t seem any better today so I called him back and ask if there was anything I could get to give her over the weekend. He explained that this antibiotic stayed in your system for about 2 weeks and it would work on her gradually. How long should it be before I seee results and does this sound like the appropriate medicine. Thank you.

    • Thank you for writing to When to expect a response depends mostly on what was wrong with your kitty. If you could write us back with the diagnosis that might help. However, if you are not seeing SOME improvement by Monday I would be in touch with the doctor. He may need to perform some laboratory tests such as Complete Blood Count (CBC), Chemistry Profile and Urinalysis. She may also need a Feline Leukemia Virus and Feline Immunodeficiency Virus test. Feel free to write back with an update, or more questions should they arise.
      Thanks for reading, Dr. Randolph

  162. Sir, my vet administered the long lasting Convenia to my fourteen year old dog. He is drinking water well enough but his appetite has dropped drastically. We can get him to only take a few morsels of his favorite dog food at a time. Hardly nothing at all. This is starting to worry us. My question, is this a side effect from the shot and if so, how long would you estimate before he regains his appetite? Thank you very much. G.McKinney

    • Loss of appetite is an unusual side effect of Convenia, occurring in less than 7% of cases during approval clinical trials. It is more likely that the disease process for which your pet’s doctor is using Convenia is causing the loss of appetite. Call him first thing Monday morning and discuss this complication with him. He may need to see your pet for followup.

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